Naloxol is an
opioid antagonist
An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors.
Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the ...
closely related to
naloxone
Naloxone, sold under the brand names Narcan (4 mg) and Kloxxado (8 mg) among others, is a medication used to reverse or reduce the effects of opioids. It is commonly used to counter decreased breathing in opioid overdose. Effects begin withi ...
. It exists in two
isomeric forms, α-naloxol and β-naloxol.
α-naloxol is a human
metabolite of naloxone. Synthetically, α-naloxol can be prepared from naloxone by
reduction of the
ketone group, and β-naloxol can be prepared from α-naloxol by a
Mitsunobu reaction
The Mitsunobu reaction is an organic reaction that converts an alcohol into a variety of functional groups, such as an ester, using triphenylphosphine and an azodicarboxylate such as diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylat ...
.
Naloxol can be said to be the
oxymorphol
Oxymorphol is oxymorphone which has been hydrogenated at the 6-position and consists of a mixture of 4,5α-Epoxy-17-methylmorphinan-3,6β,14-triol and 4,5α-Epoxy-17-methylmorphinan-3,6α,14-triol (hydromorphinol).
. It is produced by the human ...
analogue of naloxone.
See also
*
Naloxegol
Naloxegol (INN; PEGylated naloxol; trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. It was a ...
References
4,5-Epoxymorphinans
Human drug metabolites
Mu-opioid receptor antagonists
Allyl compounds
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