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A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure produced by the skin and is a
skin appendage Skin appendages (or adnexa of skin) are anatomical skin-associated structures that serve a particular function including sensation, contractility, lubrication and heat loss in animals. In humans, some of the more common skin appendages are hairs ...
, nail diseases have a distinct classification as they have their own signs and symptoms which may relate to other medical conditions. Some nail conditions that show signs of infection or inflammation may require medical assistance.


Diseases

*''Onychia'' is an inflammation of the nail folds (surrounding tissue of the nail plate) of the nail with formation of
pus Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during bacterial or fungal infection. An accumulation of pus in an enclosed tissue space is known as an abscess, whereas a visible collection ...
and shedding of the nail. Onychia results from the introduction of microscopic pathogens through small wounds. *''
Onychocryptosis An ingrown nail, also known as onychocryptosis from el, ὄνυξ () 'nail' and () 'hidden', is a common form of nail disease. It is an often painful condition in which the nail (anatomy), nail grows so that it cuts into one or both sides of ...
'', commonly known as "ingrown nails" (''unguis incarnatus''), can affect either the fingers or the toes. In this condition, the nail cuts into one or both sides of the nail bed, resulting in inflammation and possibly infection. The relative rarity of this condition in the fingers suggests that pressure from the ground or shoe against the toe is a prime factor. The movements involved in walking or other physical disturbances can contribute to the problem. Mild
onychocryptosis An ingrown nail, also known as onychocryptosis from el, ὄνυξ () 'nail' and () 'hidden', is a common form of nail disease. It is an often painful condition in which the nail (anatomy), nail grows so that it cuts into one or both sides of ...
, particularly in the absence of infection, can be treated by trimming and rounding the nail. More advanced cases, which usually include infection, are treated by surgically excising the ingrowing portion of the nail down to its bony origin and thermally or chemically
cauterizing Cauterization (or cauterisation, or cautery) is a medical practice or technique of burn (injury), burning a part of a body to remove or close off a part of it. It destroys some tissue in an attempt to mitigate bleeding and damage, remove an undes ...
the matrix, or 'root', to prevent recurrence. This surgery is called
matrixectomy Surgical treatments of ingrown toenails include a number of different options. If conservative treatment of a minor ingrown toenail does not succeed or if the ingrown toenail is severe, surgical management by a podiatrist is recommended. The i ...
. The best results are achieved by cauterizing the matrix with phenol. The Vandenbos Procedure is a highly effective method that focuses on excision of excessive nail fold tissue without affecting the healthy nail and nail matrix. The Vandenbos Procedure is showing high success rates in eliminating onychocryptosis without altering the normal nail. Another, much less effective, treatment is excision of the matrix, sometimes called a 'cold steel procedure'. *''
Onychodystrophy A nail is a claw-like plate found at the tip of the fingers and toes on most primates. Nails correspond to the claws found in other animals. Fingernails and toenails are made of a tough protective protein called alpha-keratin, which is a polymer. ...
'' is a deformation of the nails that can result from cancer chemotherapy which includes bleomycin, hydroxyurea, or
5-fluorouracil Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancrea ...
. It can include discoloration of the nail, or dyschromia. *''
Onychogryposis Onychogryphosis is a hypertrophy that may produce nails resembling claws or a ram's horn. Causes Onychogryphosis may be caused by trauma or peripheral vascular disease, but most often secondary to self-neglect and failure to cut the nails for ...
'', also called "ram's-horn nail", is a thickening and increase in
curvature In mathematics, curvature is any of several strongly related concepts in geometry. Intuitively, the curvature is the amount by which a curve deviates from being a straight line, or a surface deviates from being a plane. For curves, the canonic ...
of the nail. It is usually the result of injury to the matrix. It may be partially
hereditary Heredity, also called inheritance or biological inheritance, is the passing on of traits from parents to their offspring; either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic inform ...
and can also occur as a result of long-term neglect. It is most commonly seen in the great toe but may be seen in other toes as well as the fingernails. An affected nail has many grooves and ridges, is brownish in color, and grows more quickly on one side than on the other. The thick curved nail is difficult to cut, and often remains untrimmed, exacerbating the problem. *'' Onycholysis'' is a loosening of the exposed portion of the nail from the nail bed, usually beginning at the free edge and continuing to the lunula. It is frequently associated with an
internal disorder Internal may refer to: *Internality as a concept in behavioural economics *Neijia, internal styles of Chinese martial arts *Neigong or "internal skills", a type of exercise in meditation associated with Daoism *''Internal (album)'' by Safia, 2016 ...
, trauma, infection,
nail fungi Nail or Nails may refer to: In biology * Nail (anatomy), toughened protective protein-keratin (known as alpha-keratin, also found in hair) at the end of an animal digit, such as fingernail * Nail (beak), a plate of hard horny tissue at the tip ...
, allergy to
nail enhancement product Nail or Nails may refer to: In biology * Nail (anatomy), toughened protective protein-keratin (known as alpha-keratin, also found in hair) at the end of an animal digit, such as fingernail * Nail (beak), a plate of hard horny tissue at the tip ...
s, or side effects of
drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...
s. *''
Onychomadesis Onychomadesis is a periodic idiopathic shedding of the nails beginning at the proximal end, possibly caused by the temporary arrest of the function of the nail matrix. One cause in children is hand, foot, and mouth disease. This generally resolves ...
'' is the separation and falling off of a nail from the nail bed. Common causes include localized infection, minor injury to the
matrix bed Matrix most commonly refers to: * ''The Matrix'' (franchise), an American media franchise ** ''The Matrix'', a 1999 science-fiction action film ** "The Matrix", a fictional setting, a virtual reality environment, within ''The Matrix'' (franchis ...
, or severe systemic illness. It is sometimes a side effect of chemotherapy or x-ray treatments for cancer. A new nail plate will form once the cause of the disease is removed. *'' Onychomycosis'', also known as ''tinea unguium'', is a contagious infection of the nail caused by the same fungal organisms which cause ringworm of the skin (''Trichophyton rubrum'' or ''T. mentagrophytes'', rarely other
trichophyton ''Trichophyton'' is a genus of fungi, which includes the parasitic varieties that cause tinea, including athlete's foot, ringworm, jock itch, and similar infections of the nail, beard, skin and scalp. Trichophyton fungi are molds characterized ...
species or ''Epidermophyton floccosum'' ). It can result in discoloration, thickening, chalkiness, or crumbling of the nails and is often treated by powerful oral medications which, rarely, can cause severe side effects including liver failure. Mild onychomycosis sometimes responds to a combination of topical antifungal medication, sometimes applied as special medicinal nail
lacquer Lacquer is a type of hard and usually shiny coating or finish applied to materials such as wood or metal. It is most often made from resin extracted from trees and waxes and has been in use since antiquity. Asian lacquerware, which may be ca ...
, and
periodic filing Periodicity or periodic may refer to: Mathematics * Bott periodicity theorem, addresses Bott periodicity: a modulo-8 recurrence relation in the homotopy groups of classical groups * Periodic function, a function whose output contains values t ...
of the nail surface. For advanced onychomycosis, especially if more than one nail is infected, systemic medication (pills) is preferred. Home remedies are often used, although their effectiveness is disputed. *''
Onychophosis Onychophosis is a localized or diffuse hyperkeratotic tissue that develops on the lateral or proximal nailfolds, within the space between the nailfolds and the nail plate, and is a common finding in the elderly. Onychophosis may involve the subungu ...
'' is a growth of horny
epithelium Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellul ...
in the nail. *'' Onychoptosis'' is the periodic shedding of one or more nails, in whole or part. This condition may follow certain diseases such as
syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, an ...
, or can result from fever, trauma,
systemic upset Systemic fundamental to a predominant social, economic, or political practice. This refers to: In medicine In medicine, ''systemic'' means affecting the whole body, or at least multiple organ systems. It is in contrast with ''topical'' or ''lo ...
s or
adverse reaction An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term complica ...
to drugs. *''
Onychorrhexis Onychorrhexis (from the Greek words ὄνυχο- ''ónycho-'', "nail" and ῥῆξις ''rhexis'', "bursting"), is a brittleness with breakage of finger or toenails that may result from hypothyroidism, anemia, anorexia nervosa or bulimia, or afte ...
'' also known as brittle nails, is brittleness with breakage of fingernails or toenails. *'' Paronychia'' is a bacterial or fungal infection where the nail and skin meet. *'' Koilonychia'' is when the nail curves upwards (becomes spoon-shaped) due to an iron deficiency. The normal process of change is: brittle nails, straight nails, spoon-shaped nails. *'' Subungual hematoma'' occurs when trauma to the nail results in a collection of blood, or
hematoma A hematoma, also spelled haematoma, or blood suffusion is a localized bleeding outside of blood vessels, due to either disease or trauma including injury or surgery and may involve blood continuing to seep from broken capillary, capillaries. A he ...
, under the nail. It may result from an acute injury or from repeated minor trauma such as running in undersized shoes. Acute subungual hematomas are quite painful, and are usually treated by releasing the blood by creating a small hole in the nail.
Drilling Drilling is a cutting process where a drill bit is spun to cut a hole of circular cross-section in solid materials. The drill bit is usually a rotary cutting tool, often multi-point. The bit is pressed against the work-piece and rotated at ra ...
and thermal cautery are common methods for creating the hole. Thermal cautery is not used on
acrylic nails Artificial nails, also known as fake nails, false nails, acrylic nails, nail extensions or nail enhancements, are extensions placed over fingernails as fashion accessories. Many artificial nail designs attempt to mimic the appearance of real f ...
because they are
flammable A combustible material is something that can burn (i.e., ''combust'') in air. A combustible material is flammable if it ignites easily at ambient temperatures. In other words, a combustible material ignites with some effort and a flammable mat ...
. *''
Onychomatricoma Onychomatricoma is a cutaneous condition characterized by a distinctive tumor of the nail matrix. This nail disease can mimic many nail problems and should be examined and biopsied by a dermatologist. In particular, a main concern is the malignan ...
'', a tumor of the nail matrix. *''Nail pemphigus'', an auto-immune disease. *'' Erythronychia'', red bands in the nail from some inflammatory conditions. *'' Melanonychia'', a black, brown or grey discoloration of the nail, with numerous causes.


Nail changes and conditions associated with them

Nail inspection can give hints to the internal condition of the body as well. Nail disease can be very subtle and should be evaluated by a dermatologist with a focus in this particular area of medicine. A nail technician may be the first to note a subtle change in nail health.


Pliability

*Brittleness is associated with iron deficiency, thyroid problems, and impaired kidney function. *Splitting and fraying are associated with psoriasis and deficiencies of folic acid, protein, and Vitamin C. *Unusual thickness is associated with circulation problems.


Shape and texture

* Nail clubbing - nails that curve down around the fingertips with nailbeds that bulge is associated with oxygen deprivation and lung, heart, or liver disease. * Koilonychia - spooning, or nails that grow upwards. Associated with
iron-deficiency anaemia Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. When onset is slow, symptoms are often vague such as feeling tired, weak, shor ...
or
vitamin B12 deficiency A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an essential micronutrient that an organism needs in small quantities for the proper functioning of its metabolism. Essential nutrien ...
. *Pitting of the nails is associated with psoriasis. *
Beau's lines Beau's lines are deep grooved lines that run from side to side on the fingernail or the toenail. They may look like indentations or ridges in the nail plate.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McG ...
are horizontal ridges in the nail. * Habit-tic deformity is a condition similar to Beau's Lines caused by long-term skin picking.


Discoloration of entire nail bed

*Yellowing of the nail bed is associated with chronic bronchitis, lymphatic problems, diabetes, and liver disorders. *Brown or copper nail beds are associated with arsenic or
copper poisoning Copper toxicity (or Copperiedus) is a type of metal poisoning caused by an excess of copper in the body. Copperiedus could occur from consuming excess copper salts, but most commonly it is the result of the genetic condition Wilson's disease and ...
, and local fungal infection. *Redness is associated with heart conditions.


Other color changes and markings

* Melanonychia (longitudinal streaking that darkens or does not grow out), especially on the thumb or big toe, may indicate subungual melanoma. *White lines across the nail ( leukonychia striata, or transverse leukonychia) may be
Mees' lines Mees' lines or Aldrich–Mees lines, also called leukonychia striata, are white lines of discoloration across the nails of the fingers and toes (leukonychia). Presentation They are typically white bands traversing the width of the nail. As the ...
or
Muehrcke's lines Muehrcke's nails or Muehrcke's lines ( apparent leukonychia striata) are changes in the fingernail that may be a sign of an underlying medical condition. The term refers to a set of one or more pale transverse bands extending all the way across th ...
. *Small white patches are known as leukonychia punctata. *Dark nails are associated with B12 deficiency. *Stains of the nail plate (not the nail bed) are associated with smoking, and henna use. *
Splinter hemorrhages Splinter hemorrhages (or haemorrhages) are tiny blood clots that tend to run vertically under the nails. Splinter hemorrhages are not specific to any particular condition, and can be associated with subacute infective endocarditis, scleroderma, tri ...
(or haemorrhages) are tiny blood clots that tend to run vertically under the nails. *Drug-induced nail changes are caused by drug usage which may result in various abnormalities.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .


Treatment

In approximately half of suspected nail fungus cases there is actually no fungal infection, but only some nail dystrophy., which cites * * Before beginning oral antifungal therapy the health care provider should confirm a fungal infection. Administration of treatment to persons without an infection is unnecessary health care and causes needless exposure to side effects.


See also

* Hangnail *
List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ...
*
Occupational hazards associated with exposure to human nail dust The use of podiatry drills, in the absence of engineering controls and personal protective equipment, is an occupational hazard to the healthcare provider. Nail dust collected during foot care procedures performed in office settings has been found ...
*
Yellow nail syndrome Yellow nail syndrome, also known as "primary lymphedema associated with yellow nails and pleural effusion", is a very rare medical syndrome that includes pleural effusions, lymphedema (due to under development of the lymphatic vessels) and yellow d ...


References


External links


Fungal Nail Infections
- explanation covering causes, treatment, and prevention


Links to pictures of Toenail Diseases (Wiggins MD)
{{DEFAULTSORT:Nail Disease Nails (anatomy) Conditions of the skin appendages