Nucleoporin 85 (Nup85) is a
protein that in humans is encoded by the ''NUP85''
gene.
Function
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.
Model organisms
Model organism
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...
s have been used in the study of NUP85 function. A conditional
knockout mouse line called ''Nup85
tm1a(KOMP)Wtsi'' was generated at the
Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.
Additional screens performed: - In-depth immunological phenotyping
References
Further reading
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Nuclear pore complex
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