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The Bernstein Network Computational Neuroscience is a research network in the field of
computational neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to u ...
; this field brings together experimental approaches in
neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...
with theoretical models and
computer simulation Computer simulation is the process of mathematical modelling, performed on a computer, which is designed to predict the behaviour of, or the outcome of, a real-world or physical system. The reliability of some mathematical models can be dete ...
s. It unites different scientific disciplines, such as physics, biology, mathematics, medical science, psychology, computer science, engineering and philosophy in the endeavor to understand how the brain functions. The close combination of neurobiological experiments with theoretical models and computer simulations allows scientists of the Bernstein Network to pursue innovative approaches with regard to one of the most complex structures nature has created in the course of evolution: the natural brain. The network started in 2004 with a funding initiative of the Federal Ministry of Education and Research (BMBF) to develop and interconnect research structures in computational neuroscience throughout Germany and to promote the transfer of theoretical insight into clinical and technical applications. It is named after the German physiologist and biophysicist
Julius Bernstein Julius Bernstein (18 December 1839 – 6 February 1917) was a German physiologist born in Berlin. His father was Aron Bernstein (1812—1884), a founder of the Reform Judaism Congregation in Berlin 1845; his son was the mathematician Felix ...
(1839-1917). His "membrane hypothesis" provided the first biophysical explanation of how nerve cells transmit and process information via electrical currents. Generating a mathematical description, he also paved the way to simulate neural brain processes in the computer. Today, the Bernstein Network consists of more than 200 research groups worldwide.


History

In 2004, the Bernstein Network started off as the "Nationales Bernstein Netzwerk Computational Neuroscience" (NNCN)) as a funding initiative of the Federal Ministry of Education and Research (BMBF). The aim of the initiative was the long-term establishment of the research discipline
Computational Neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to u ...
in Germany. As part of the high-tech strategy of the German government, the Bernstein Network has been supported with a total of about 170 million euros until now. The network includes over 200 research groups at more than 25 locations nationwide. The participating research groups were located at universities and non-university research institutes (Fraunhofer, Helmholtz, Leibniz and Max Planck institutes). Using a BMBF initial financing, 22 new professorships in the area of Computational Neuroscience were established at German universities within the framework of the Bernstein Network, which were cnsoblidated by the federal states. Scientific members of the network were involved in study programs and courses and collaborated with numerous industry partners to develop specific biomedical or technological applications (e.g.
brain computer interface A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...
,
retinal implant Retinal prostheses for restoration of sight to patients blinded by retinal degeneration are being developed by a number of private companies and research institutions worldwide. The system is meant to partially restore useful vision to people who ...
,
cochlear implant A cochlear implant (CI) is a surgically implanted neuroprosthesis that provides a person who has moderate-to-profound sensorineural hearing loss with sound perception. With the help of therapy, cochlear implants may allow for improved speech und ...
,
prosthesis In medicine, a prosthesis (plural: prostheses; from grc, πρόσθεσις, prósthesis, addition, application, attachment), or a prosthetic implant, is an artificial device that replaces a missing body part, which may be lost through trau ...
,
advanced driver-assistance systems An advanced driver-assistance system (ADAS) is any of a groups of electronic technologies that assist drivers in driving and parking functions. Through a safe human-machine interface, ADAS increase car and road safety. ADAS uses automated technol ...
,
neuromorphic Neuromorphic engineering, also known as neuromorphic computing, is the use of electronic circuits to mimic neuro-biological architectures present in the nervous system. A neuromorphic computer/chip is any device that uses physical artificial ne ...
chips). They also worked (and still do) on new diagnostic methods, therapeutic approaches, or tools for neurological or psychiatric disorders in collaboration with clinical researchers (e.g.
epilepsy Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical ...
,
tinnitus Tinnitus is the perception of sound when no corresponding external sound is present. Nearly everyone experiences a faint "normal tinnitus" in a completely quiet room; but it is of concern only if it is bothersome, interferes with normal hearin ...
,
amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most comm ...
,
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
,
stroke A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...
, depression,
schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...
).


Structure

Six Bernstein Centers (in Berlin,
Freiburg Freiburg im Breisgau (; abbreviated as Freiburg i. Br. or Freiburg i. B.; Low Alemannic: ''Friburg im Brisgau''), commonly referred to as Freiburg, is an independent city in Baden-Württemberg, Germany. With a population of about 230,000 (as o ...
, Göttingen, Heidelberg-Mannheim, Munich and Tübingen) form the basic structure of the Bernstein Network. As additional local structural elements, five Bernstein groups have been established (in Bochum, Bremen, Heidelberg, Jena, and Magdeburg). Eleven Bernstein Collaborations link the Bernstein Centers with diverse research groups widely distributed over Germany. Since 2006, the BMBF has annually allocated the Bernstein Award to an outstanding young scientist in the research field of Computational Neuroscience. The award is endowed with up to 1,25 million euros over five years, and allows to establish an independent junior research group at a German research institution. Since 2008 and 2009, respectively, the Bernstein Network comprehends two research foci, which explore the first steps towards applications. The'' Bernstein Focus: Neurotechnology'' includes 4 local collaborative projects (in Berlin, Göttingen, Frankfurt and Freiburg-Tübingen); the'' Bernstein Focus: Neuronal Basis of Learning'' comprises eight collaborative projects.


Integration into the international research landscape

The German INCF Node (G-Node) connects the Bernstein Network with the international network of the
International Neuroinformatics Coordinating Facility The International Neuroinformatics Coordinating FacilityINCF is an international non-profit organization with the mission to develop, evaluate, and endorse standards and best practices that embrace the principles of Open, FAIR, and Citable neuros ...
. Since 2010, the
BMBF The Federal Ministry of Education and Research (german: link=no, Bundesministerium für Bildung und Forschung, ), abbreviated BMBF, is a cabinet-level ministry of Germany. It is headquartered in Bonn, with an office in Berlin. The Ministry provi ...
promotes German-American cooperation projects in the field of computational neuroscience within the framework of the Bernstein Network and the CRCNS program in cooperation with the
National Science Foundation (NSF) The National Science Foundation (NSF) is an independent agency of the United States government that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is the National I ...
and the National Institutes of Health (NIH). In a cooperation between the
BMBF The Federal Ministry of Education and Research (german: link=no, Bundesministerium für Bildung und Forschung, ), abbreviated BMBF, is a cabinet-level ministry of Germany. It is headquartered in Bonn, with an office in Berlin. The Ministry provi ...
, German Research Foundation (DFG), and the
Japan Science and Technology Agency The Japan Science and Technology Agency (JST; Japanese: 科学技術振興機構) is a Japanese government agency which aims to build infrastructure that supports knowledge creation and dissemination in Japan. It is one of the , overseen by the Mi ...
(JST), German-Japan Collaboration projects have been launched in 2012.


Bernstein Conference

Th
Bernstein Conference
is the largest annual Computational Neuroscience conference in Europe attracting an international audience from across the world. Until 2017, it was organized by members of the Bernstein Network at annually changing locations. In the years 2018 - 2022, the Bernstein Conferences takes place in Berlin. The conference offers a broad overview over the topics of Computational Neuroscience and Neurotechnology.


Membership

In 2009, members of the Bernstein Network founded a non-profit association, the Bernstein Association Computational Neuroscience, aiming at promoting science, research, and teaching in
Computational Neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to u ...
and the communication of research contents and results to the public.Website of Bernstein Association Computational Neuroscience
/ref> The Bernstein Network Computational Neuroscience is open to all researchers in the field or related subjects. Individual membership must be supported by two active Bernstein members
Further information.


Literature

*
Peter Dayan Peter Dayan is director at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany. He is co-author of ''Theoretical Neuroscience'', an influential textbook on computational neuroscience. He is known for applying Bayesian metho ...
, Larry F. Abbott: "Theoretical neuroscience: computational and mathematical modeling of neural systems". MIT Press, Cambridge, Mass 2001, . *
William Bialek William Samuel Bialek (born 1960, in Los Angeles, California) is a theoretical biophysicist and a professor at Princeton University and The Graduate Center, CUNY. Much of his work, which has ranged over a wide variety of theoretical problems at t ...
, Fred Rieke, David Warland, Rob de Ruyter van Steveninck: "Spikes: exploring the neural code". MIT Press, Cambridge, Mass 1999, . *David Sterratt, Bruce Graham, Andrew Gillies, David Willshaw: "Principles of Computational Modelling in Neuroscience". Cambridge University Press, 2011, * Sonja Grün, Stefan Rotter (eds.): „Analysis of Parallel Spike Trains“, Springer Series in Computational Neuroscience, 2010. * Hanspeter A. Mallot: "Computational Neuroscience: A first course", Springer Series in Bio-/Neuroinformatics, 2013. *
James M. Bower James Mason Bower (born February 17, 1954 in Northampton, Massachusetts) is an American neuroscientist and CEO and chairman of the Board of Numedeon Inc., creator of the Whyville.net educational virtual world. He graduated from McQuaid Jesuit Hi ...
(ed.): "20 years of Computational Neuroscience", Springer Series in Computational Neuroscience, 2013.


Links


Website of the Bernstein Network Computational NeuroscienceWebsite of the Bernstein ConferenceGerman Neuroinformatics Node of the INCF (G-Node)International Neuroinformatics Coordinating Facility (INCF)


References

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