Nucleoside diphosphate kinase A is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''NME1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
It is thought to be a
metastasis suppressor
A metastasis suppressor is a protein that acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer. Metastasis is one of the most lethal cancer processes. This process is responsible for about nine ...
.
Function
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.
Interactions
NME1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
Aurora A kinase
Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the ''AURKA'' gene.
Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during ...
,
*
CD29
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ''ITGB1'' gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen r ...
*
NME3
Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the ''NME3'' gene.
Interactions
NME3 has been shown to interact with NME1 and NME2.
Clinical significance
Mutations in this gene have been associated with congenital ...
,
*
Protein SET
Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the ''SET'' gene.
Interactions
Protein SET has been shown to interact with:
* Acidic leucine-rich nuclear phosphoprotein 32 family member A,
* CDK5R1,
* KLF5 ...
,
*
RAR-related orphan receptor alpha
RAR-related orphan receptor alpha (RORĪ±), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the ''RORA'' gene. RORĪ± participates in the transcriptional regulation of some g ...
,
*
RAR-related orphan receptor beta
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the ''RORB'' gene.
Function
The protein encoded by this gene is a member of ...
,
[ and
* ]TERF1
Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the ''TERF1'' gene.
Gene
The human TERF1 gene is located in the chromosome 8 at 73,921,097-73,960,357 bp. Two transcripts of this gene are alternatively spliced produ ...
.
See also
*Nucleoside-diphosphate kinase
Nucleoside-diphosphate kinases (NDPKs, also NDP kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of terminal phosphate between different nucleoside diphosphates (NDP) and triphosphates (NTP) ...
References
Further reading
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{{PDB Gallery, geneid=4830