NKX-homeodomain factors are a family of
homeodomain
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full ...
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
s that are critical regulators of organ
development
Development or developing may refer to:
Arts
*Development hell, when a project is stuck in development
*Filmmaking, development phase, including finance and budgeting
*Development (music), the process thematic material is reshaped
* Photograph ...
.
Human genes that encode NKX-homeodomain factors include:
*
NKX1-1,
NKX1-2
*
NKX2-1
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the ''NKX2-1'' gene.
Function
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription (genetics ...
,
NKX2-2
Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the ''NKX2-2'' gene.
Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome ...
,
NKX2-4
Marine Corps Air Station Miramar (MCAS Miramar) , formerly Naval Auxiliary Air Station (NAAS) Miramar and Naval Air Station (NAS) Miramar, is a United States Marine Corps installation that is home to the 3rd Marine Aircraft Wing, which is the av ...
,
NKX2-8
*
NKX3-1
Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the ''NKX3-1'' gene located on chromosome 8p. ''NKX3-1'' is a prostatic tumor suppressor gene.
''NKX3-1'' is an androgen-reg ...
,
NKX3-2
NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of ''bagpipe (bap)'' in ''Drosophila'' and therefore also known as Bapx1 (bagpipe homeobox homolog 1). The protein encoded by this gene is a homeodomain containing transcriptio ...
*
NKX6-1
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the ''NKX6-1'' gene.
Function
In the pancreas, NKX6.1 is required for the development of beta cell
Beta cells (β-cells) are a type of cell found in pancreatic islets that ...
,
NKX6-2
Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the ''NKX6-2'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' o ...
,
NKX6-3
References
{{Transcription factors, g3
Developmental genes and proteins
Transcription factors