NF-kappa-B inhibitor zeta (IκBζ) is a
protein that in humans is encoded by the ''NFKBIZ''
gene.
This gene is a member of the ankyrin-repeat family and is induced by
lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the
ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in
inflammatory responses to LPS by their interaction with
NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different
isoforms have been found for this gene.
Clinical relevance
''NFKBIZ'' has been implicated as an oncogene in diffuse large B-cell lymphoma (DLBCL). Specifically, genomic locus containing this gene is recurrently amplified in copy number in the activated B-cell (ABC) subgroup of DLBCL.
More recently, a recurrence of somatic mutations affecting the 3-prime untranslated region of ''NFKBIZ'' were found to promote NFKBIZ expression in ABC DLBCL.
IκBζ is required for expression of the
SASP CCL2 (MCP1)
cytokine, which recruits macrophages to remove cancer cells.
The
flavonoid
Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans.
Chemically, flavonoids ...
apigenin has been shown to reduce
gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...
of IκBζ.
References
Further reading
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