Modulibacteria is a bacterial phylum formerly known as KS3B3 or GN06. It is a

candidate A candidate, or nominee, is the prospective recipient of an award or honor, or a person seeking or being considered for some kind of position; for example: * to be elected to an office — in this case a candidate selection procedure occurs. * ...

phylum, meaning there are no cultured representatives of this group. Members of the Modulibacteria phylum are known to cause fatal filament overgrowth (bulking) in high-rate industrial

anaerobic Anaerobic means "living, active, occurring, or existing in the absence of free oxygen", as opposed to aerobic which means "living, active, or occurring only in the presence of oxygen." Anaerobic may also refer to: * Anaerobic adhesive, a bonding a ...

wastewater treatment

bioreactor A bioreactor refers to any manufactured device or system that supports a biologically active environment. In one case, a bioreactor is a vessel in which a chemical process is carried out which involves organisms or biochemically active substances ...

s. The Modulibacteria phylum was first proposed in 2006 by two independent research groups based on analyses of

16S rRNA 16S rRNA may refer to: * 16S ribosomal RNA 16 S ribosomal RNA (or 16 S rRNA) is the RNA component of the 30S subunit of a prokaryotic ribosome ( SSU rRNA). It binds to the Shine-Dalgarno sequence and provides most of the SSU structure. The g ...

gene sequences. One group recovered Modulibacteria sequences from the a

hypersaline A hypersaline lake is a landlocked body of water that contains significant concentrations of sodium chloride, brines, and other salts, with saline levels surpassing that of ocean water (3.5%, i.e. ). Specific microbial species can thrive in hi ...

microbial mat from Guerrero Negro (Baja California Sur, Mexico) and used the provisional name GN06 for the novel phylum, while the other recovered sequences from sulfur-rich black mud marine sediments (CA, USA) and used the provisional name KSB3. The first genomic insights into the phylum were achieved in 2015, at which time the name "Modulibacteria" was proposed. Two genomes were recovered from methanogenic sludge samples of a full-scale upflow anaerobic sludge blanket (UASB) reactor treating a high-strength organic

wastewater Wastewater is water generated after the use of freshwater, raw water, drinking water or saline water in a variety of deliberate applications or processes. Another definition of wastewater is "Used water from any combination of domestic, industrial ...

discharged from a food-processing factory. Through a combination of genome-based metabolic reconstruction and microscopic observation, it was determined that the two studied Modulibacteria species (''Moduliflexus flocculans'' and ''Vecturithrix granuli'') produce filamentous structures and are

Gram-negative Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation. They are characterized by their cell envelopes, which are composed of a thin peptidoglycan cell wa ...

, strictly anaerobic

fermenter Industrial fermentation is the intentional use of fermentation in manufacturing products useful to humans. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. ...

s capable of non- flagellar based gliding motility. Both have an unusually large number of sensory and response

regulator gene A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcrip ...

s compared to other bacteria. Members of the Modulibacteria phylum have been detected in a variety of environments in addition to bioreactors and hypersaline mats, such as wetland sediments
FJ516883.1
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dolphin A dolphin is an aquatic mammal within the infraorder Cetacea. Dolphin species belong to the families Delphinidae (the oceanic dolphins), Platanistidae (the Indian river dolphins), Iniidae (the New World river dolphins), Pontoporiidae (the ...

mouth, and a tubeworm from a coldseep
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Taxonomy

The following taxonomy was proposed by Sekiguchi et al. 2015. Phylogeny by Annotree v1.2.0 which uses the GTDB 05-RS95 (

Genome Taxonomy Database The Genome Taxonomy Database (GTDB) is an online database that maintains information on a proposed nomenclature of prokaryotes, following a phylogenomic approach based on a set of conserved single-copy proteins. In addition to breaking up paraph ...

References

{{Bacteria classification, state=expanded Bacteria phyla Candidatus taxa