Membrane-spanning 4A genes are members of the

CD20-like family In molecular biology, the CD20-like family of proteins includes the CD20 protein and the beta subunit of the high affinity receptor (biochemistry), receptor for IgE Fc, MS4A2. MS4A2 has a tetrameric protein, tetrameric secondary structure, structur ...

. The MS4A genes are usually organized in a single genomic clusters in mammals, suggestive of

gene duplication Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. It can be defined as any duplication of a region of DNA that contains a gene. ...

events. MS4A genes encode a class of four-transmembrane spanning proteins. MS4A genes have been described to act as a specific kind of olfactory receptor in the necklace

olfactory sensory neurons An olfactory receptor neuron (ORN), also called an olfactory sensory neuron (OSN), is a sensory neuron within the olfactory system. Structure Humans have between 10 and 20 million olfactory receptor neurons (ORNs). In vertebrates, ORNs are b ...

in mice ( Mus musculus).Greer PL, Bear DM, Lassance JM, Bloom ML, Tsukahara T, Pashkovski SL, Masuda FK, Nowlan AC, Kirchner R, Hoekstra HE, et al. 2016. A family of non-GPCR chemosensors defines an alternative logic for mammalian olfaction. Cell. 165:1734–1748
doi: 10.1016/j.cell.2016.05.001
In human (''

Homo sapiens Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, ...

'') the members of this family include: * MS4A1 (better known as "CD20") *

MS4A2 High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the ''MS4A2'' gene. Function The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the rele ...

MS4A3 Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the ''MS4A3'' gene. This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structura ...

* MS4A4A * MS4A4E * MS4A5 * MS4A6A * MS4A6E *

MS4A7 Membrane-spanning 4-domains subfamily A member 7 is a protein that in humans is encoded by the ''MS4A7'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." m ...

* MS4A8B * MS4A9 *

MS4A10 B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. In humans CD20 is encoded by the ''MS4A1'' gene. This gene ...

MS4A12 B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. In humans CD20 is encoded by the ''MS4A1'' gene. This gene ...

* MS4A13 * MS4A14 * MS4A15 * MS4A18

References

Gene families {{genetics-stub