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Marguerite Davis (September 16, 1887 – September 19, 1967) was an American biochemist, co-discoverer of
vitamin A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an essential micronutrient that an organism needs in small quantities for the proper functioning of its metabolism. Essential nutri ...
s A and B with Elmer Verner McCollum in 1913. Their research greatly influenced later research on nutrition.


Personal life

Davis was born on September 16, 1887 in Racine, Wisconsin to Jefferson J. Davis, a local physician and botanist, who taught at the University of Wisconsin. In his 1964 autobiography, McCollum says that Davis was physically handicapped by severe burns that she received at age ten while playing at a
bonfire A bonfire is a large and controlled outdoor fire, used either for informal disposal of burnable waste material or as part of a celebration. Etymology The earliest recorded uses of the word date back to the late 15th century, with the Catho ...
when her clothing caught fire. Her background and scientific interests led her to enroll at the University of Wisconsin in 1906. In 1908, she transferred to the University of California at Berkeley and received her bachelor of science degree in
home economics Home economics, also called domestic science or family and consumer sciences, is a subject concerning human development, personal and family finances, consumer issues, housing and interior design, nutrition and food preparation, as well as texti ...
in 1910. After graduation, she returned to the
University of Wisconsin A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, t ...
where she completed some graduate work, but did not complete a master's degree. At the University of Wisconsin, she began her work as a research assistant with McCollum. In 1940, Davis retired, returning to her hometown of Racine to live with her brother, John Archibald “Archie” Davis, in their family home. Davis pursued history and gardening after her retirement, and was active in local civic affairs. She was recognized for her contributions as a civic leader by Racine's Women's Civic Council in 1958. Davis died in Racine three days after her eightieth birthday on September 19, 1967.


Discovery of vitamins A and B

Davis worked as an assistant for McCollum, caring for a large rat colony and helping expand it. Davis helped McCollum carry out "ten or more times as many experiments as ealone could manage". They were attempting to create mixtures that could replace food in animal diets, specifically studying trace chemicals in foods that are essential to life. These substances were called "vitamines", as they hypothesized that they were the organic molecule "amines". In 1913, Davis and McCollum identified what they called "fat-soluble A", a substance found in fats that is essential to life. They distinguished it from another substance described by Dutch chemist Christiaan Eijkman, which they studied and called "water-soluble B." These were later renamed Vitamins A and B, after long research on rats. The discovery of two vitamins paved the way to further research in nutrition. Their discovery of fat-soluble Vitamin A and water-soluble Vitamin B was first published in the
Journal of Biological Chemistry The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research ...
in 1913 in the paper "The Necessity of Certain Lipids in the Diet during Growth". In his 1964 autobiography, McCollum attributes his success in nutrition research to two people: Davis and Stephen Babcock. Davis worked in McCollum's lab from 1909 to 1916. McCollum asked annually for a salary for Davis, but was denied up until her last year. She was unpaid for 5 years, and was paid $600 in her sixth, and final year. After Davis left Madison, the rat colony that Davis helped build and care for was cared for by Nina Simmonds from 1916-1929.


Career

Davis founded the nutrition laboratory at the University of Wisconsin. She briefly moved to New Jersey, to work for the Squibb Pharmaceutical Company and later helped
Rutgers University Rutgers University (; RU), officially Rutgers, The State University of New Jersey, is a Public university, public land-grant research university consisting of four campuses in New Jersey. Chartered in 1766, Rutgers was originally called Queen's ...
form a nutrition lab as part of its Ernest Mario School of Pharmacy. In 1940, she returned to the University of Wisconsin to teach and do research for a number of years.


Notes


External links


House on the Hill - with short biography and photo of Marguerite Davis
{{DEFAULTSORT:Davis, Marguerite 1887 births 1967 deaths 20th-century American chemists American women biochemists Vitamin researchers 20th-century American women scientists