M83 or M-83 may refer to:

Astronomy

* Messier 83, a spiral galaxy in the constellation Hydra ** M83 Group, a group of galaxies centered around Messier 83

Military

* M-83, a Soviet M-class submarine * M83 Survey of modern US hand grenades#M8.2C_M83_and_Model_308-1_White_Smoke, smoke grenade * M83 submunition, a US copy of the German Butterfly Bomb of World War II; used in the M29 cluster bomb

Music

* M83 (band), an electronic band named after the galaxy of the same name ** M83 (album), ''M83'' (album), the debut album of the M83 music group

Roads and routes

* M-83 (Michigan highway), a state highway in Michigan {{Letter-NumberCombDisambig