Mycoplasmataceae is a family of
bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
in the order Mycoplasmatales. This family consists of the genera ''
Mycoplasma
''Mycoplasma'' is a genus of bacteria that, like the other members of the class ''Mollicutes'', lack a cell wall around their cell membranes. Peptidoglycan (murein) is absent. This characteristic makes them naturally resistant to antibiotics ...
'' and ''
Ureaplasma
''Ureaplasma'' is a genus of bacteria belonging to the family Mycoplasmataceae. As the name imples, ''Ureaplasma'' is urease positive.
Phylogeny
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenc ...
''.
In 1967, the order Mycoplasmatales was incorporated into the class Mollicutes. Many species are sexually transmitted and cause
pelvic inflammatory disease
Pelvic inflammatory disease, also known as pelvic inflammatory disorder (PID), is an infection of the upper part of the female reproductive system, namely the uterus, fallopian tubes, and ovaries, and inside of the pelvis. Often, there may be no ...
.
Taxonomy
''Mycoplasma''
''Mycoplasma ''refers to a
genus
Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus com ...
of
bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
that lack a
cell wall
A cell wall is a structural layer surrounding some types of cells, just outside the cell membrane. It can be tough, flexible, and sometimes rigid. It provides the cell with both structural support and protection, and also acts as a filtering mech ...
and possess a three-layered cellular membrane.
They can be
parasitic
Parasitism is a close relationship between species, where one organism, the parasite, lives on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The entomologist E. O. Wilson has c ...
or
saprotrophic
Saprotrophic nutrition or lysotrophic nutrition is a process of chemoheterotrophic extracellular digestion involved in the processing of decayed (dead or waste) organic matter. It occurs in saprotrophs, and is most often associated with fungi (f ...
. Several species are sexually transmitted and
pathogen
In biology, a pathogen ( el, πάθος, "suffering", "passion" and , "producer of") in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a germ ...
ic in humans. Others are found on cats, dogs, and barnyard fowl.
''Ureaplasma''
''Ureaplasma'' is the second of two genera of
bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
belonging to the family Mycoplasmataceae. As the name implies, ureaplasma is
urease
Ureases (), functionally, belong to the superfamily of amidohydrolases and phosphotriesterases. Ureases are found in numerous bacteria, fungi, algae, plants, and some invertebrates, as well as in soils, as a soil enzyme. They are nickel-containin ...
positive. This genera is distinct from other genera in
Mollicutes
Mollicutes is a class of bacteria distinguished by the absence of a cell wall. The word "Mollicutes" is derived from the Latin ''mollis'' (meaning "soft" or "pliable"), and ''cutis'' (meaning "skin"). Individuals are very small, typically only 0. ...
in that it hydrolyses urea for generation of ATP.
''Ureaplasma'' ''spp.'' as human pathogens
Both ''
Ureaplasma urealyticum
''Ureaplasma urealyticum'' is a bacterium belonging to the genus ''Ureaplasma'' and the family Mycoplasmataceae in the order Mycoplasmatales. This family consists of the genera ''Mycoplasma'' and ''Ureaplasma''. Its type strain is T960. There are ...
'' and ''
Ureaplasma parvum'' have been identified as important human pathogens, causing infection in the urogenital tract and, rarely, at distal sites.
Their role in neonatal disease and adverse pregnancy outcomes has been well established, and semantic classifications are changing to reflect the nature of the detrimental outcomes these infections are associated with. In the 2010s, ''
Mycoplasma genitalium
''Mycoplasma genitalium'' (''MG'', commonly known as Mgen) is a sexually transmitted, small and pathogenic bacterium that lives on the mucous epithelial cells of the urinary and genital tracts in humans. Medical reports published in 2007 and 201 ...
'' has been re-classified as an
STI, and it is likely that with more research, ''Ureaplasma spp''. will follow this trend. Similar to other pathogens such as ''
Chlamydia trachomatis
''Chlamydia trachomatis'' (), commonly known as chlamydia, is a bacterium that causes chlamydia, which can manifest in various ways, including: trachoma, lymphogranuloma venereum, nongonococcal urethritis, cervicitis, salpingitis, pelvic inflamma ...
'', infection with ''Ureaplasma spp.'' is associated with adverse fertility outcomes in both men and women. Both cause
non-gonococcal urethritis
Nongonococcal urethritis (NGU) is an inflammation of the urethra that is not caused by gonorrheal infection.
For treatment purposes, doctors usually classify infectious urethritis in two categories: gonococcal urethritis, caused by gonorrhea, ...
. ''Ureaplasma spp.'' were implicated in conditions such as
prostatitis
Prostatitis is an umbrella term for a variety of medical conditions that incorporate bacterial and non-bacterial origin illnesses in the pelvic region. In contrast with the plain meaning of the word (which means "inflammation of the prostate"), the ...
and
chronic pelvic pain syndrome
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), previously known as chronic nonbacterial prostatitis, is long-term pelvic pain and lower urinary tract symptoms (LUTS) without evidence of a bacterial infection. It affects about 2–6% ...
as early as the 1980s. Research in women has lagged several decades behind, but it is now becoming more clear how ''Ureaplasma spp.'' contribute to etiologies such as
interstitial cystitis
Interstitial cystitis (IC), a type of bladder pain syndrome (BPS), is chronic pain in the bladder and pelvic floor of unknown cause. It is the urologic chronic pelvic pain syndrome of women. Symptoms include feeling the need to urinate right awa ...
/
painful bladder syndrome. ''Ureaplasma spp.'' are associated with alterations in host environment that increase susceptibility to other infections such as
bacterial vaginosis
Bacterial vaginosis (BV) is a disease of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urination ...
and
vaginal candidiasis. ''Ureaplasma spp.'' can cause
reactive arthritis
Reactive arthritis, also known as Reiter's syndrome, is a form of inflammatory arthritis that develops in response to an infection in another part of the body (cross-reactivity). Coming into contact with bacteria and developing an infection can ...
as well as directly infect the
synovium
The synovial membrane (also known as the synovial stratum, synovium or stratum synoviale) is a specialized connective tissue that lines the inner surface of capsules of synovial joints and tendon sheath. It makes direct contact with the fibrous ...
.
Some case studies have suggested a causative role in
complex regional pain syndrome/
reflex sympathetic dystrophy syndrome.
Phylogeny
The currently accepted taxonomy is based on the
List of Prokaryotic names with Standing in Nomenclature
List of Prokaryotic names with Standing in Nomenclature (LPSN) is an online database that maintains information on the naming and taxonomy of prokaryotes, following the taxonomy requirements and rulings of the International Code of Nomenclature ...
(LPSN) and
National Center for Biotechnology Information
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH). It is approved and funded by the government of the United States. The ...
(NCBI)
See also
*
List of bacterial orders
This article lists the orders of the Bacteria. The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI)
and the phylogeny is based on 16S ...
*
List of bacteria genera This article lists the genera of the bacteria. The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). However many taxonomic names are ...
References
External links
Ureaplasma Infection: eMedicine Infectious Diseases
{{Taxonbar, from=Q136808
Mollicutes
Bacteria families