''Murid gammaherpesvirus 4'' (MuHV-4) is a species of

virus A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1 ...

in the genus ''

Rhadinovirus ''Rhadinovirus'' (synonyms: ''Rhadinoviridae'' and gamma-2 herpesviruses) is a genus of viruses in the order ''Herpesvirales'', in the family ''Herpesviridae'', in the subfamily ''Gammaherpesvirinae''. Humans and other mammals serve as natural h ...

''. It is a member of the subfamily ''

Gammaherpesvirinae ''Gammaherpesvirinae'' is a subfamily of viruses in the order ''Herpesvirales'' and in the family ''Herpesviridae''. Viruses in ''Gammaherpesvirinae'' are distinguished by reproducing at a more variable rate than other subfamilies of ''Herpesvir ...

'' in the family ''

Herpesviridae ''Herpesviridae'' is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ''ἕρπειν ...

''. This species infects mice via the nasal passages and causes an acute

infectious mononucleosis Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). Most people are infected by the virus as children, when the disease produces few or no symptoms. In young adult ...

-like syndrome with elevated levels of

leukocytes White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from mult ...

, and shifts in the relative proportion of

lymphocytes A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adap ...

along with the appearance of atypical mononuclear cells. ''Murid gammaherpesvirus 4'' currently serves as a model for study of human gammaherpesvirus

pathogenesis Pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. The word comes from Greek πάθος ''pat ...

Strains

Seven strains of ''Murid gammaherpesvirus 4'' have been isolated, including the following six: * MuHV-Šum * MuHV-60 * MuHV-68 * MuHV-72 * MuHV-76 * MuHV-4556

References

{{Taxonbar, from=Q6938568 Gammaherpesvirinae Animal viral diseases Rodent diseases