Multicenter Automatic Defibrillator Implantation Trial and MADIT II are

implantable cardioverter defibrillator An implantable cardioverter-defibrillator (ICD) or automated implantable cardioverter defibrillator (AICD) is a device implantable inside the body, able to perform defibrillation, and depending on the type, cardioversion and pacing of the h ...

(or ICD) trials which investigate whether prophylactic ICD therapy in moderately high-risk

coronary Coronary () may, as shorthand in English, be used to mean: * Coronary circulation, the system of arteries and veins in mammals ** Coronary artery disease **Coronary occlusion ** A myocardial infarction, a heart attack As adjective * Referring to ...

patients (in addition to conventional therapy) would significantly reduce death compared with patients treated with conventional therapy alone. The MADIT II trial started in 1997 and ended in 2001 where the safety committee stopped the study because the benefits were already statistically significant. The study included patients with a prior

myocardial infarction A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may ...

and an

ejection fraction An ejection fraction (EF) is the volumetric fraction (or portion of the total) of fluid (usually blood) ejected from a chamber (usually the heart) with each contraction (or heartbeat). It can refer to the cardiac atrium, ventricle, gall bladder, ...

less than or equal to 30%. The results were a reduction in mortality of 31% compared to patients receiving conventional therapy alone.

References

Cardiology Clinical trials related to cardiology {{Treatment-stub