MtlS RNA is a small
non-coding RNA found in
Vibrio cholerae
''Vibrio cholerae'' is a species of Gram-negative, facultative anaerobe and comma-shaped bacteria. The bacteria naturally live in brackish or saltwater where they attach themselves easily to the chitin-containing shells of crabs, shrimps, and oth ...
and related bacteria. MtlS is found in the
mannitol operon, which encodes the mannitol-specific
phosphotransferase
Phosphotransferases are a category of enzymes ( EC number 2.7) that catalyze phosphorylation reactions. The general form of the reactions they catalyze is:
:A-P + B \rightleftharpoons B-P + A
Where ''P'' is a phosphate group and A and B are the do ...
system. The MtlS RNA is expressed when the bacteria are grown on carbon sources other than mannitol. MtlS is responsible for the
post-transcriptional regulation of the
MtlA protein. Overexpression of MtlS
represses MtlA synthesis; it is proposed that this repression occurs as MtlS
base pair
A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA ...
s with the mtlA
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein.
mRNA is ...
and occludes the
ribosome binding site A ribosome binding site, or ribosomal binding site (RBS), is a sequence of nucleotides upstream of the start codon of an mRNA transcript that is responsible for the recruitment of a ribosome during the initiation of translation. Mostly, RBS refers t ...
, thus inhibiting synthesis of the mannitol-specific phosphotransferase system.
References
External links
*
Non-coding RNA
{{molecular-cell-biology-stub