Mrs. O'Leary's Cow can refer to
* The cow belonging to Mrs.
Catherine O'Leary, often blamed in folklore for starting the
Great Chicago Fire
The Great Chicago Fire was a conflagration that burned in the American city of Chicago during October 8–10, 1871. The fire killed approximately 300 people, destroyed roughly of the city including over 17,000 structures, and left more than 10 ...
of 1871
*
"Mrs. O'Leary's Cow" (instrumental), an instrumental song by Brian Wilson
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