Mostafa Ronaghi ( fa, مصطفی رونقی; born 1968) is an Iranian
molecular biologist
Molecular biology is the branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interact ...
, specializing in
DNA sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. Th ...
methodology. He earned his Ph.D. from the
Royal Institute of Technology in Sweden in 1998.
, he is the Chief Technology Officer and Senior Vice President at
Illumina. Prior to this position, he was a principal investigator and Senior Research Associate at the
Stanford Genome Technology Center at
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
, focusing on developing analytical techniques for molecular diagnostics.
He is principal investigator for several grants including grants from the
National Human Genome Research Institute
The National Human Genome Research Institute (NHGRI) is an institute of the National Institutes of Health, located in Bethesda, Maryland.
NHGRI began as the Office of Human Genome Research in The Office of the Director in 1988. This Office transi ...
(NHGRI), part of the
National Institutes of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
for the development of array-based
Pyrosequencing
Pyrosequencing is a method of DNA sequencing (determining the order of nucleotides in DNA) based on the "sequencing by synthesis" principle, in which the sequencing is performed by detecting the nucleotide incorporated by a DNA polymerase. Pyrosequ ...
.
In 1998, he described together with
Pål Nyren an
Mathias Uhlena solution-based variant of the
pyrosequencing
Pyrosequencing is a method of DNA sequencing (determining the order of nucleotides in DNA) based on the "sequencing by synthesis" principle, in which the sequencing is performed by detecting the nucleotide incorporated by a DNA polymerase. Pyrosequ ...
technology and co-founded Pyrosequencing AB (renamed to Biotage in 2003). He co-invented Molecular Inversion Probe assay and co-founded ParAllele BioScience to develop this multiplexed technology for genetic testing. ParAllele was acquired by
Affymetrix in May 2005.
In 2005, he co-founded
NextBio, a search engine for life science data that was acquired by Illumina in 2013. He also serves on the board of directors of IntegenX and Aurora Biofuels. In 2008, Ronaghi and
Helmy Eltoukhy co-founded
Avantome, a DNA sequencing company that was acquired by Illumina in July 2008.
tradingmarkets.com , 2008 Release: Illumina To Acquire Privately-Held Avantome For $25 Million In Cash Upfront
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Publications
Among his approximately 50 peer-reviewed journal articles are the publications describing Pyrosequencing and Molecular Inversion Probe assays and other techniques:
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He also holds about 20 patents.
References
* yrosequencing Array for DNA Sequencing
External links
Stanford Genome Technology Center
NextBio
IntegenX, Inc.
Aurora Biofuels
{{DEFAULTSORT:Ronaghi, Mostafa
1968 births
Living people
KTH Royal Institute of Technology alumni
American people of Iranian descent
Iranian biologists
Iranian expatriate academics
Iranian chief technology officers