Morris Goodman (1925 – November 14, 2010,

Michigan Michigan () is a state in the Great Lakes region of the upper Midwestern United States. With a population of nearly 10.12 million and an area of nearly , Michigan is the 10th-largest state by population, the 11th-largest by area, and the ...

) was an American scientist known for his work in

molecular evolution Molecular evolution is the process of change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations. The field of molecular evolution uses principles of evolutionary biology and population genetics ...

and

molecular systematics Molecular phylogenetics () is the branch of phylogeny that analyzes genetic, hereditary molecular differences, predominantly in DNA sequences, to gain information on an organism's evolutionary relationships. From these analyses, it is possible to ...

. Goodman was a distinguished professor at the Center for Molecular Medicine and Genetics at

Wayne State University School of Medicine The Wayne State University School of Medicine (WSUSOM) is the medical school of Wayne State University, a public research university in Detroit, Michigan. It enrolls more than 1,500 students in undergraduate medical education, master's degree, Ph ...

, editor-in-chief of the journal ''

Molecular Phylogenetics and Evolution ''Molecular Phylogenetics and Evolution'' is a peer-reviewed scientific journal of evolutionary biology and phylogenetics. The journal is edited by E.A. Zimmer. Indexing The journal is indexed in: *EMBiology *Journal Citation Reports *Scopus ...

'', and a member of the

anthropology Anthropology is the scientific study of humanity, concerned with human behavior, human biology, cultures, societies, and linguistics, in both the present and past, including past human species. Social anthropology studies patterns of behavi ...

section of the

United States National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

Life and work

Goodman grew up in

Milwaukee, Wisconsin Milwaukee ( ), officially the City of Milwaukee, is both the most populous and most densely populated city in the U.S. state of Wisconsin and the county seat of Milwaukee County, Wisconsin, Milwaukee County. With a population of 577,222 at th ...

, and spent many years in

Detroit, Michigan Detroit ( , ; , ) is the largest city in the U.S. state of Michigan. It is also the largest U.S. city on the United States–Canada border, and the seat of government of Wayne County. The City of Detroit had a population of 639,111 at ...

as the only Wayne State University faculty member appointed to the National Academy of Science until his death on November 14, 2010. After high school, he attended the

University of Wisconsin-Madison A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the ...

for one year, then in 1943 entered the

Army Air Forces The United States Army Air Forces (USAAF or AAF) was the major land-based aerial warfare service component of the United States Army and ''de facto'' aerial warfare service branch of the United States during and immediately after World War II ...

, where he served as a navigator for the remainder of

World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...

. He was married in 1946, shortly after returning to college. He became interested in science after a

comparative anatomy Comparative anatomy is the study of similarities and differences in the anatomy of different species. It is closely related to evolutionary biology and phylogeny (the evolution of species). The science began in the classical era, continuing in t ...

course; the professor, Harold Wolfe, recruited him as a teaching assistant. Goodman graduated with a degree in

zoology Zoology ()The pronunciation of zoology as is usually regarded as nonstandard, though it is not uncommon. is the branch of biology that studies the Animal, animal kingdom, including the anatomy, structure, embryology, evolution, Biological clas ...

and a minor in

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

, and continued on at Wisconsin for his master's and Ph.D. degrees under Wolfe (a former student of

Alan Boyden Alan may refer to: People *Alan (surname), an English and Turkish surname *Alan (given name), an English given name **List of people with given name Alan ''Following are people commonly referred to solely by "Alan" or by a homonymous name.'' * A ...

). Upon finishing a dissertation on the antigen-antibody

precipitin A precipitin is an antibody which can precipitate out of a solution upon antigen binding. Precipitin reaction The precipitin reaction provided the first quantitative assay for antibody. The precipitin reaction is based upon the interaction of anti ...

reaction, he went to

Caltech The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

for post-doctoral work, supported by an

NIH The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

fellowship.Interview with Morris Goodman
, July 28, 2004, conducted by Joel Hagen. From ''Perspectives on Molecular Evolution'' website, by Michael R. Dietrich. Accessed August 19, 2007. Working with

Dan Campbell Daniel Allen Campbell (born April 13, 1976), nicknamed "Motor City Dan Campbell", or "MCDC" for short, is an American football coach and a former tight end who is the head coach for the Detroit Lions of the National Football League (NFL). He pr ...

at Caltech (within the Division of Chemistry headed by

Linus Pauling Linus Carl Pauling (; February 28, 1901August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific top ...

), Goodman worked on the immunological properties of

hemoglobin Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...

s, including the immunological differences between normal and

sickle-cell Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blo ...

hemoglobin. According to a 2004 interview, Goodman became interested in evolutionary problems around 1957–1958. After research stints at the

University of Illinois Medical School The University of Illinois College of Medicine offers a four-year program leading to the MD degree at four different sites in Illinois: Chicago, Peoria, Illinois, Peoria, Rockford, Illinois, Rockford, and formerly Champaign–Urbana metropolitan a ...

and the

Detroit Institute of Cancer Research Detroit ( , ; , ) is the largest city in the U.S. state of Michigan. It is also the largest U.S. city on the United States–Canada border, and the seat of government of Wayne County. The City of Detroit had a population of 639,111 at the ...

, he embarked—with his friend Morris Wilson—on studies of the degree of variability in proteins expressed early vs. late in development. By 1961, Goodman's comparative immunology research produced some results, particularly on the evolutionary relationships among

primate Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including huma ...

s, that were attracting interest from evolutionary biologists. He presented his ideas at the

New York Academy of Sciences The New York Academy of Sciences (originally the Lyceum of Natural History) was founded in January 1817 as the Lyceum of Natural History. It is the fourth oldest scientific society in the United States. An independent, nonprofit organization wit ...

and the

Wenner-Gren Foundation for Anthropological Research Axel Lennart Wenner-Gren (5 June 1881 – 24 November 1961) was a Swedish entrepreneur and one of the wealthiest men in the world during the 1930s. Early life He was born on 5 June 1881 in Uddevalla, a town on the west coast of Sweden. He w ...

. At the latter meeting, he and two others using molecular approaches to evolutionary problems (

Emile Zuckerkandl Émile Zuckerkandl (July 4, 1922 – November 9, 2013) was an Austrian-born French biologist considered one of the founders of the field of molecular evolution. He introduced, with Linus Pauling, the concept of the "molecular clock", which enabl ...

and

Harold Klinger Harold may refer to: People * Harold (given name), including a list of persons and fictional characters with the name * Harold (surname), surname in the English language * András Arató, known in meme culture as "Hide the Pain Harold" Arts a ...

) were confronted by three of the "framers" of the modern evolutionary synthesis:

Ernst Mayr Ernst Walter Mayr (; 5 July 1904 – 3 February 2005) was one of the 20th century's leading evolutionary biologists. He was also a renowned Taxonomy (biology), taxonomist, tropical explorer, ornithologist, Philosophy of biology, philosopher o ...

G. G. Simpson George Gaylord Simpson (June 16, 1902 – October 6, 1984) was an American paleontologist. Simpson was perhaps the most influential paleontologist of the twentieth century, and a major participant in the modern synthesis, contributing ''Tempo a ...

, and

Theodosius Dobzhansky Theodosius Grigorievich Dobzhansky (russian: Феодо́сий Григо́рьевич Добржа́нский; uk, Теодо́сій Григо́рович Добржа́нський; January 25, 1900 – December 18, 1975) was a prominent ...

. During the early

history of molecular evolution The history of molecular evolution starts in the early 20th century with "comparative biochemistry", but the field of molecular evolution came into its own in the 1960s and 1970s, following the rise of molecular biology. The advent of protein sequ ...

, traditional evolutionists were both interested in and apprehensive about the advent of molecular techniques to evolutionary biology; Simpson later referred to Goodman as "an old friendly antagonist.". Through the 1960s and 1970s, Goodman continued his evolutionary work based on

serology Serology is the scientific study of Serum (blood), serum and other body fluids. In practice, the term usually refers to the medical diagnosis, diagnostic identification of Antibody, antibodies in the serum. Such antibodies are typically formed in r ...

, eventually with graduate students working under him. In the 1970s he also started using

protein sequence Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesi ...

data for his molecular taxonomy work. In a 1975 paper in ''

Nature Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...

'', Goodman and his collaborators used sequence data to reconstruct the evolutionary history of hemoglobin (including possible ancestral sequences) and analyze which sites on the hemoglobin complex had evolved at which stages. Goodman called this the first "hard evidence of Darwinian evolution". In 1982, with another ''Nature'' paper, Goodman did the same for the

DNA sequence DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. Th ...

s of the hemoglobin genes.

References

External links

Morris Goodman faculty profile
– Wayne State University School of Medicine
Lawrence I. Grossman and Derek E. Wildman, "Morris Goodman", Biographical Memoirs of the National Academy of Sciences (2014)
{{DEFAULTSORT:Goodman, Morris Evolutionary biologists Members of the United States National Academy of Sciences American anthropologists American immunologists 1925 births 2010 deaths University of Wisconsin–Madison alumni Wayne State University faculty United States Army Air Forces officers United States Army Air Forces personnel of World War II