Mofegiline (MDL-72,974) is a
selective,
irreversible inhibitor
Inhibitor or inhibition may refer to:
In biology
* Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity
* Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotra ...
of
monoamine oxidase B (MAO-B) and
semicarbazide-sensitive amine oxidase
Primary-amine oxidase, also known as semicarbazide-sensitive amine oxidase (SSAO), is an enzyme () with the systematic name ''primary-amine:oxygen oxidoreductase (deaminating)''. This enzyme catalyses the following chemical reaction
: RCH2NH2 + H ...
(SSAO) which was under investigation for the treatment of
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
and
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...
,
but was never marketed.
See also
*
Ladostigil
Ladostigil (TV-3,326) is a novel neuroprotective agent being investigated for the treatment of neurodegenerative disorders like Alzheimer's disease, Lewy body disease, and Parkinson's disease. It acts as a reversible acetylcholinesterase and but ...
*
Lazabemide
*
Rasagiline
*
Selegiline
Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. It is provided in the form of a capsule or ...
References
{{Monoamine metabolism modulators
Abandoned drugs
Antidementia agents
Antiparkinsonian agents
Monoamine oxidase inhibitors