Route 74 is a highway in Cape Girardeau County, Missouri. The western terminus is at Route 25 in Dutchtown. Its eastern terminus is at the

Illinois Illinois ( ) is a state in the Midwestern United States. Its largest metropolitan areas include the Chicago metropolitan area, and the Metro East section, of Greater St. Louis. Other smaller metropolitan areas include, Peoria and Rockf ...

state line at the

Mississippi River The Mississippi River is the second-longest river and chief river of the second-largest drainage system in North America, second only to the Hudson Bay drainage system. From its traditional source of Lake Itasca in northern Minnesota, it fl ...

Cape Girardeau Cape Girardeau ( , french: Cap-Girardeau ; colloquially referred to as "Cape") is a city in Cape Girardeau and Scott Counties in the U.S. state of Missouri. At the 2020 census, the population was 39,540. The city is one of two principal citi ...

. The road continues into Illinois as Illinois Route 146. No other towns are on the route. Route 74 is one of the original state highways. It has remained unchanged since it was created in 1922.

Major intersections

References

074 Transportation in Cape Girardeau County, Missouri {{Missouri-road-stub