Route 53 is a highway in southeastern

Missouri Missouri is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it is bordered by eight states (tied for the most with Tennessee ...

. Its southern terminus is at Route 25 in Holcomb. Its northern terminus is at Business U.S. Route 67 Business in

Poplar Bluff Poplar Bluff is a medium city in Butler County in Southeast Missouri, United States. It is the county seat of Butler County and is known as "The Gateway to the Ozarks" among other names. The population was 16,225 at the 2020 census. The Poplar B ...

. Route 53 is one of the original state highways and has remained essentially unchanged since 1922.

Major intersections

References

053 53 may refer to: * 53 (number) * one of the years 53 BC, AD 53, 1953, 2053 * FiftyThree, an American privately held technology company that specializes in tools for mobile creation and visual thinking * 53rd Regiment Alabama Cavalry * 53rd Regiment ...

Transportation in Butler County, Missouri Transportation in Dunklin County, Missouri {{Missouri-road-stub