Mirosław Jan Stasik
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Mirosław Jan Stasik (born 27 January 1929 r. in Łódź) is a
Polish Polish may refer to: * Anything from or related to Poland, a country in Europe * Polish language * Poles, people from Poland or of Polish descent * Polish chicken *Polish brothers (Mark Polish and Michael Polish, born 1970), American twin screenwr ...
medical doctor A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
and research toxicologist.


Education and early career

Stasik graduated from Łódź School of Medicine (now Medical University of Łódź) and later studied toxicology at the
University of Surrey The University of Surrey is a public research university in Guildford, Surrey, England. The university received its royal charter in 1966, along with a number of other institutions following recommendations in the Robbins Report. The institut ...
, United Kingdom. He obtained his Dr Med. at the Heidelberg University, Germany's oldest university. In the 1960s he completed his training in internal medicine, and became director of the newly created clinical department of acute poisoning at the
Nofer Institute of Occupational Medicine The Nofer Institute of Occupational Medicine (NIOM) is a state-owned research institute in Łódź, Poland. It is the leading institute in the field of occupational and environmental health in Poland, and has the status of WHO Collaborating Centre. ...
in Łódz. There he also pioneered in the field of poison control centers in Poland. During this period he published one of the first clinical works devoted to acute toxicity of tetraethyllead in humans. This substance was commonly used as an antiknock agent in gasoline until 2005.


Further career

Since 1970 he has been living in Germany, with two breaks for training at the Institute of Toxicology of the University of Würzburg and for university study in the UK. In Frankfurt he directed a centre of toxicology and epidemiology within the department of occupational medicine of a chemical concern Hoechst AG. His research was focused on defining the carcinogenic potential of some aromatic amines, e.g.
3,3'-dichlorobenzidine 3,3'-Dichlorobenzidine is an organic compound with the formula (C6H3Cl(NH2))2. The pure compound is pale yellow, but commercial samples are often colored. It is barely soluble in water and is often supplied as a wet paste. It is widely used in the ...
and derivatives of aniline, as well as ethylene oxide and formaldehyde. In the 1980s Stasik represented Hoechst at scientific conferences of the
Chemical Industry Institute of Toxicology A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., wit ...
(USA), as well as symposiums of the Center for Environmental Epidemiology, University of Pittsburgh. These were organized in co-operation with the United States Environmental Protection Agency. He was also a member of the Ecology and Toxicology Centre and the European Chemical Industry Council (CEFIC) in Brussels. In recent years he co-operated with the Institute of Social, Occupational and Environmental Medicine at the
Gutenberg University The Johannes Gutenberg University Mainz (german: Johannes Gutenberg-Universität Mainz) is a public university, public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. With approx ...
, as well as with the Department of Histology and Embryology of the Medical University of Łódź in order to continue and to publish his works on carcinogenic aromatic amines.


Main achievements

In Frankfurt, while investigating simple
arylamine In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituent such a ...
s, Stasik discovered that
4-chloro-o-toluidine 4-Chloro-''o''-toluidine (4-COT, 4-chloro-2-methylaniline) is the organic compound with the formula CH3C6H3Cl(NH2). It is a colorless solid. The compound is produced as an intermediate to the pesticide chlordimeform and a precursor to some azo d ...
(4-COT), used as an intermediate for the manufacture of
dye A dye is a colored substance that chemically bonds to the substrate to which it is being applied. This distinguishes dyes from pigments which do not chemically bind to the material they color. Dye is generally applied in an aqueous solution an ...
stuffs, pigments, and chlordimeform a pesticide, causes cancer of the urinary bladder in humans. As a direct consequence of this discovery a worldwide ban was imposed on production and use of this arylamine. Professor Klaus Norpoth in his handbook of occupational medicine mentions Mirosław Stasik for the discovery of the cancer risk of 4-COT as one of 15 international researchers, who over two centuries discovered occupational carcinogenic substances, starting from Percivall Pott (1775), through
Ludwig Rehn Ludwig Wilhelm Carl Rehn (13 April 1849, Bad Sooden-Allendorf – 29 May 1930) was a German surgeon. Rehn was born in 1849, in the village of Allendorf, the youngest of five children. After the visiting the convent school in Bad Hersfeld, he studi ...
(1895), John Creech and
Maurice Johnson Maurice Johnson may refer to: *Maurice Johnson (English politician) (1480–1551), English politician, Member of the Parliament of England for Stamford 1523–c.1539 *Maurice Johnson (antiquary) (1688–1755), British antiquary *Maurice Johnson (Can ...
(1974) to Stasik (1987). Stasik is an author and co-author of several dozen publications in international journals, articles in
International Labour Office The International Labour Organization (ILO) is a United Nations agency whose mandate is to advance social and economic justice by setting international labour standards. Founded in October 1919 under the League of Nations, it is the first and ol ...
''Encyklopedia of Occupational Health and Safety'' (four editions) and in ''Ullmann's Enzyklopaedie''. Since 1997 he has been leading a branch of
Societas Jablonoviana Consensu or obligatio consensu or obligatio consensu contracta or obligations ex consensuGeorge Bowyer, ''Commentaries on the Modern Civil Law'' (London: V & R Stevens and G S Norton, 1848), chapter 26p 201 or contractus ex consensu or contracts co ...
in Wiesbaden. This scientific society was founded in Leipzig in 1774 by a Polish aristocrat Józef A. Jabłonowski.


4-COT Foundation

In 2001, together with his wife Dr Liliana Stasik, he set up the 4-COT Foundation,X Krajowy Zjazd Naukowy Polskiego Towarzystwa Medycyny Pracy
which sponsors studies of young Polish researchers in Western Europe and Canada.


References

{{DEFAULTSORT:Stasik Polish toxicologists People in health professions from Łódź 1929 births Living people