Miriam (Mika) Salpeter (née Mark) (April 8, 1929 — October 24, 2000) was an American academic. As professor of neurobiology at

Cornell University Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach an ...

, she developed quantitative electron microscopic

autoradiograph An autoradiograph is an image on an X-ray film or nuclear emulsion produced by the pattern of decay emissions (e.g., beta particles or gamma rays) from a distribution of a radioactive substance. Alternatively, the autoradiograph is also available ...

y as a means to investigate the

neuromuscular junction A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. Muscles require innervation to ...

. The

Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well kn ...

created the Mika Salpeter Lifetime Achievement Award in her honour.

Early life and education

Salpeter was born in

Riga Riga (; lv, Rīga , liv, Rīgõ) is the capital and largest city of Latvia and is home to 605,802 inhabitants which is a third of Latvia's population. The city lies on the Gulf of Riga at the mouth of the Daugava river where it meets the Ba ...

. Her father was a

Yiddish Yiddish (, or , ''yidish'' or ''idish'', , ; , ''Yidish-Taytsh'', ) is a West Germanic language historically spoken by Ashkenazi Jews. It originated during the 9th century in Central Europe, providing the nascent Ashkenazi community with a ver ...

scholar and Salpeter was fluent in

. During the rise of

Nazi Germany Nazi Germany (lit. "National Socialist State"), ' (lit. "Nazi State") for short; also ' (lit. "National Socialist Germany") (officially known as the German Reich from 1933 until 1943, and the Greater German Reich from 1943 to 1945) was ...

Salpeter emigrated from

Latvia Latvia ( or ; lv, Latvija ; ltg, Latveja; liv, Leţmō), officially the Republic of Latvia ( lv, Latvijas Republika, links=no, ltg, Latvejas Republika, links=no, liv, Leţmō Vabāmō, links=no), is a country in the Baltic region of ...

Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tot ...

, before moving to the

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...

in 1945. Salpeter attended high school in

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

. She was an undergraduate student at

Hunter College Hunter College is a public university in New York City. It is one of the constituent colleges of the City University of New York and offers studies in more than one hundred undergraduate and postgraduate fields across five schools. It also admi ...

, where she was a member of

Phi Beta Kappa The Phi Beta Kappa Society () is the oldest academic honor society in the United States, and the most prestigious, due in part to its long history and academic selectivity. Phi Beta Kappa aims to promote and advocate excellence in the liberal a ...

and graduated Suma cum laude. Salpeter moved to

for her doctoral studies, where she earned a PhD under the supervision of Howard Liddell. She spent a year at the

Australian National University The Australian National University (ANU) is a public research university located in Canberra, the capital of Australia. Its main campus in Acton encompasses seven teaching and research colleges, in addition to several national academies and ...

before returning to

as a postdoctoral fellow with Marcus Singer. Singer's laboratory was based in the Zoology department, where she studied cells using an

electron microscope An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a hi ...

. Salpeter was appointed a research associate in the Singer lab in 1961 and soon after promoted to Senior Research Associate.

Research and career

Neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...

was an emerging field at the start of Salpeter's research career, and she decided to concentrate her efforts on the

. The

is a synapse that controls all voluntary movement, the formation of which was extensively investigated by Salpeter throughout her research career. In particular Salpeter looked at the role of

acetylcholine receptor An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Classification Like other transmembrane receptors, acetylcholine receptors are classified according ...

s. Salpeter struggled to secure a faculty position at

– Singer, her biggest advocate in the department, moved to

Case Western Reserve University Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reser ...

, and the academic community were not welcoming to women. Salpeter did not let this atmosphere faze her, and continued her research as a non-faculty member. In 1967 Salpeter was recruited to the

Section of Neurobiology and Behavior. Here she worked in the laboratory of Benjamin Siegel and was supported by the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

. She spent a year in the laboratory of

Vincent Wigglesworth Sir Vincent Brian Wigglesworth CBE FRS (17 April 1899 – 11 February 1994) was a British entomologist who made significant contributions to the field of insect physiology. He established the field in a textbook which was updated in a number ...

at the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

. In 1973 Salpeter was promoted to Professor. She developed quantitative electron microscopic

y, and demonstrated it as a sensitive means to study the

. Salpeter collaborated with her husband, astronomer and physicist

Edwin Ernest Salpeter Edwin Ernest Salpeter (3 December 1924 – 26 November 2008,) was an Austrian–Australian–American astrophysicist. Life Born in Vienna to a Jewish family, Salpeter emigrated from Austria to Australia while in his teens to escape the Nazis. He ...

, on the interactions between nerves and muscle fibres.

Awards and honours

The

created the Mika Salpeter Lifetime Achievement Award in her honour. Her awards and honours include: *

Patricia Goldman-Rakic Hall of Honor *Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

*Hall of Fame of the

City University of New York The City University of New York ( CUNY; , ) is the Public university, public university system of Education in New York City, New York City. It is the largest urban university system in the United States, comprising 25 campuses: eleven Upper divis ...

*Marcus Singer Award

Selected publications

* * *

Personal life

Salpeter married

in 1950. Together they had two daughters, Judy and Shelley. At the age of 71 she was diagnosed with

thyroid cancer Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck. C ...

. She continued to visit her laboratory everyday until the day that she died.

References

{{DEFAULTSORT:Salpeter, Miriam Cornell University alumni Cornell University faculty 1929 births 2000 deaths Latvian emigrants to Canada American neuroscientists American women neuroscientists Canadian emigrants to the United States