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Miriam Rossi is an Italian-American chemist and the Mary Landon Sague Chair at
Vassar College Vassar College ( ) is a private liberal arts college in Poughkeepsie, New York, United States. Founded in 1861 by Matthew Vassar, it was the second degree-granting institution of higher education for women in the United States, closely follo ...
. She works on
x-ray crystallography X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...
and chemistry education.


Early life and education

Rossi was born in Italy and moved to
New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...
as a child. She studied
chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
at
Hunter College Hunter College is a public university in New York City. It is one of the constituent colleges of the City University of New York and offers studies in more than one hundred undergraduate and postgraduate fields across five schools. It also admi ...
, where she worked with David Beveridge. She was the first in her family to have attained a PhD degree. In fact, her parents, in Italy, had a 4th grade education, the maxiumum available at the time. Her older brother, Egidio Rossi, is a nephrologist in Parma, Italy. She joined
Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...
for her doctoral studies, earning a PhD in
inorganic chemistry Inorganic chemistry deals with synthesis and behavior of inorganic and organometallic compounds. This field covers chemical compounds that are not carbon-based, which are the subjects of organic chemistry. The distinction between the two disci ...
under the supervision of Tom Kistenmacher. She worked on the refinement of
1-methylcytosine 1-Methylcytosine is a methylated form of the DNA base cytosine. In 1-methylcytosine, a methyl group is attached to the 1st atom in the 6-atom ring. This methyl group distinguishes 1-methylcytosine from cytosine. History Miriam Rossi worked o ...
.


Research and career

Rossi joined the
Fox Chase Cancer Center Fox Chase Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center research facility and hospital located in the Fox Chase section of Philadelphia, Pennsylvania, United States. The main facilities of the center are loca ...
as a postdoctoral
fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...
with
Jenny Glusker Jenny Pickworth Glusker (born 28 June 1931) is a British biochemist and crystallographer. Since 1956 she has worked at the Fox Chase Cancer Center, a National Cancer Research Institute in the United States. She was also an adjunct professor of ...
. Here she determined the structure of methylcobalamin, an active compound of Vitamin B12. In 1982 Rossi joined
Vassar College Vassar College ( ) is a private liberal arts college in Poughkeepsie, New York, United States. Founded in 1861 by Matthew Vassar, it was the second degree-granting institution of higher education for women in the United States, closely follo ...
. She uses
X-ray crystallography X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...
to study the structure and function of molecules, particularly those with
biological activity In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or ...
. She has investigated several biological molecules, including quercetin, curcumin and
resveratrol Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources ...
. Rossi identified the bioactivity of curcumin. At Vassar College, Rossi supervised
Cathy Drennan Catherine (Cathy) Drennan is an American biochemist and crystallographer. She is the John and Dorothy Wilson Professor of Biochemistry professor at the Massachusetts Institute of Technology and a professor at the Howard Hughes Medical Institute ...
, and has continued to act as her mentor. She served on the US National Committee for Crystallography and is currently a member of the International Union of Crystallography Commission on Education. Rossi has been involved with teaching crystallography and chemistry throughout her academic career. She is responsible for teaching structural chemistry and biochemistry. At Vassar she led the ''Culture and Chemistry of Cuisine'' course. In the class, students learn about fermentation, leavening and the behaviour of starches. She has worked with
The Culinary Institute of America The Culinary Institute of America (CIA) is a private culinary school with its primary campus in Hyde Park, New York, and branch campuses in St. Helena and Napa, California; San Antonio, Texas; and Singapore. The college, which was the first t ...
on their culinary science program. After being asked to speak about the nutritional benefits of the Mediterranean diet, Rossi became interested in the scientific origins. She collaborated with an
olive oil Olive oil is a liquid fat obtained from olives (the fruit of ''Olea europaea''; family Oleaceae), a traditional tree crop of the Mediterranean Basin, produced by pressing whole olives and extracting the oil. It is commonly used in cooking: f ...
producer in
California California is a U.S. state, state in the Western United States, located along the West Coast of the United States, Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the List of states and territori ...
and found that olive oil limited the growth of
tumour cells A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
and had strong
antioxidant Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. This can lead to polymerization and other chain reactions. They are frequently added to industrial products, such as fuels and lubricant ...
properties. Working with undergraduate students from Vassar College, Rossi investigated the health improving properties of
goji berries Goji, goji berry, or wolfberry () is the fruit of either ''Lycium barbarum'' or ''Lycium chinense'', two closely related species of boxthorn in the nightshade family, Solanaceae. ''L. barbarum'' and ''L. chinense'' fruits are simil ...
; using
X-ray diffraction X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...
to determine the structure of β-ionone, emodin and cnidium. She also looked at hispolon, a compound that is found in
mushroom A mushroom or toadstool is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground, on soil, or on its food source. ''Toadstool'' generally denotes one poisonous to humans. The standard for the name "mushroom" is t ...
s from
East Asia East Asia is the eastern region of Asia, which is defined in both geographical and ethno-cultural terms. The modern states of East Asia include China, Japan, Mongolia, North Korea, South Korea, and Taiwan. China, North Korea, South Korea and ...
. She was made the Mary Landon Sague Professor of Chemistry in 2008. Rossi worked on initiatives to advance women faculty memberships into leadership positions. She has developed mentoring schemes and cyber networking opportunities. She looked at horizontal peer mentoring for senior women at
liberal arts college A liberal arts college or liberal arts institution of higher education is a college with an emphasis on undergraduate study in liberal arts and sciences. Such colleges aim to impart a broad general knowledge and develop general intellectual capac ...
s. In 2017 Rossi was named at the Diamond Level of the
Mid-Hudson The Hudson Valley (also known as the Hudson River Valley) comprises the valley of the Hudson River and its adjacent communities in the U.S. state of New York. The region stretches from the Capital District including Albany and Troy south to Yo ...
section of the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
.


Publications

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References

{{DEFAULTSORT:Rossi, Miriam American crystallographers American people of Italian descent Vassar College faculty Hunter College alumni Johns Hopkins University alumni