Mirandola Biomedical District
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The Mirandola Biomedical District ( it, Distretto biomedicale di Mirandola) is an
industrial district Industrial district concept was initially used by Alfred Marshall to describe some aspects of the industrial organisation of nations. Industrial district (ID) is a place where workers and firms, specialised in a main industry and auxiliary indus ...
in the
biomedical engineering Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to medicine and biology for healthcare purposes (e.g., diagnostic or therapeutic). BME is also traditionally logical sciences ...
, specialised in the production of
medical devices A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assura ...
such as equipment and disposable products for therapeutic applications, located in the
Mirandola Mirandola ( Mirandolese: ) is a city and ''comune'' of Emilia-Romagna, Italy, in the Province of Modena, northeast of the provincial capital by railway. History Mirandola originated as a Renaissance city-fortress. For four centuries it was ...
area and in some neighbouring municipalities such as
Medolla Medolla ( Mirandolese: ) is a ''comune'' (municipality) in the Province of Modena in the Italian region Emilia-Romagna, located about northwest of Bologna and about northeast of Modena. Medolla borders the following municipalities: Bomporto, C ...
,
Concordia sulla Secchia Concordia sulla Secchia ( Concordiese: ) is a ''comune'' (municipality) in the Province of Modena in the Italian region Emilia-Romagna, located about northwest of Bologna and about north of Modena. Concordia sulla Secchia borders the following ...
,
Cavezzo Cavezzo ( Mirandolese: ) is a ''comune'' (municipality) in the Province of Modena in the Italian region Emilia-Romagna, located about northwest of Bologna and about northeast of Modena. Cavezzo borders the following municipalities: Carpi, Medo ...
,
San Felice sul Panaro San Felice sul Panaro ( Sanfeliciano: ) is a ''comune'' (municipality) in the province of Modena in the Italian region Emilia-Romagna, located about northwest of Bologna and about northeast of Modena. San Felice sul Panaro since Roman times ha ...
,
San Possidonio San Possidonio ( Mirandolese: ) is a ''comune'' (municipality) in the Province of Modena in the Italian region Emilia-Romagna, located about northwest of Bologna and about northeast of Modena. San Possidonio borders the following municipalities: ...
, San Prospero, and Poggio Rusco. The Mirandola Biomedical District is considered the most important in the sector in Europe and third in the world, after
Minneapolis Minneapolis () is the largest city in Minnesota, United States, and the county seat of Hennepin County. The city is abundant in water, with thirteen lakes, wetlands, the Mississippi River, creeks and waterfalls. Minneapolis has its origins ...
and
Los Angeles Los Angeles ( ; es, Los Ángeles, link=no , ), often referred to by its initials L.A., is the List of municipalities in California, largest city in the U.S. state, state of California and the List of United States cities by population, sec ...
in the
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for this reason the area is called as the 'Italian
Silicon Valley Silicon Valley is a region in Northern California that serves as a global center for high technology and innovation. Located in the southern part of the San Francisco Bay Area, it corresponds roughly to the geographical areas San Mateo Coun ...
of biomedicals'. In the 1970s, the Mirandola area saw a great influx of industry in the biomedical field, witnessing the birth of numerous companies specialising in the production of disposable biomedical devices: the area of great industrial density that was coming to life became the soul of the current biomedical district, which is still expanding. During the eighties and nineties, the number of companies in the area grew considerably, bringing production specialisation to very high levels. In 2012, on the occasion of the 50th anniversary of the birth of the first biomedical company, a museum specialising in the history and early products of Mirandola Biomedical District has been set up in the city's historic centre. The numerous companies in the district now cater for a very wide range of healthcare areas, including
haemodialysis Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of purifying the blood of a person whose kidneys are not working normally. This type of dialysis achieves the extracorporeal removal of waste products such as creatini ...
,
cardiac surgery Cardiac surgery, or cardiovascular surgery, is surgery on the heart or great vessels performed by cardiac surgeons. It is often used to treat complications of ischemic heart disease (for example, with coronary artery bypass grafting); to co ...
, anesthesia e
intensive care medicine Intensive care medicine, also called critical care medicine, is a medical specialty that deals with seriously or critically ill patients who have, are at risk of, or are recovering from conditions that may be life-threatening. It includes pro ...
,
apheresis Apheresis ( ἀφαίρεσις (''aphairesis'', "a taking away")) is a medical technology in which the blood of a person is passed through an apparatus that separates out one particular constituent and returns the remainder to the circulation ...
e
plasmapheresis Plasmapheresis (from the Greek πλάσμα, ''plasma'', something molded, and ἀφαίρεσις ''aphairesis'', taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulati ...
,
blood transfusion Blood transfusion is the process of transferring blood products into a person's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but mo ...
,
nutrition Nutrition is the biochemical and physiological process by which an organism uses food to support its life. It provides organisms with nutrients, which can be metabolized to create energy and chemical structures. Failure to obtain sufficient ...
, gynaecology. The production specialisation of the companies in the Mirandola Biomedical District concerns disposable plastic products for medical use and equipment for dialysis, cardiac surgery, transfusion and other healthcare applications. The production of disposables accounts for more than 80% of the total, while biomedical equipment accounts for 13%. The district produces both finished products and the components needed to make disposables.


History


Origin and development

The district was born in the 1960s, thanks to the initiative of Mario Veronesi, a pharmacist who realised the potential of the market for disposable products for medical use. In his small assembly workshop (Miraset, with only three employees), he studied and developed a new prototype of an
artificial kidney Artificial kidney is often a synonym for hemodialysis, but may also refer to the other renal replacement therapies (with exclusion of kidney transplantation) that are in use and/or in development. This article deals mainly with bioengineered ki ...
, one of the most sophisticated of the few that were being produced. From this initial nucleus, technicians and investors (including Veronesi himself) broke away several times to set up their own business projects and found other companies. Since 2000, the favourable economic performance of these companies has attracted the interest of foreign investors and large multinationals attracted by the technological capabilities of the area, resulting in numerous changes of ownership and industrial concentration and contributing to local development. The result is an entrepreneurial fabric characterised by a strong projection towards foreign markets and, at the same time, by a tendency to concentrate strategic and innovative activities, accompanied by the widespread diffusion of service and manufacturing activities, which are decentralised outside and entrusted to small local companies.


2012 earthquake

In May 2012, a series of earthquakes devastated, along with other towns in Emilia, the northern area of the province of Modena, especially Mirandola and the neighbouring municipalities. The biomedical district suffered very serious damage from 20 May onwards, aggravated by the devastating tremor of magnitude 5.8 on 29 May, whose epicentre was just 2 km from the industrial area of San Giacomo Roncole and caused the death of four people crushed by the rubble of the Aries and BBG companies. In spite of the very serious disruption, the companies in the district tried to start up again immediately so as not to interrupt production. The fact that many large companies belonged to international industrial groups and that many warehouses were covered by insurance against natural events (including earthquakes) meant that the financial resources needed to rebuild and restart were found more quickly than the aid promised by the state. According to a 2015 survey, only 16.4% of companies had received state compensation three years after the earthquake. As early as 2014, lay-offs were no longer being used, while between 2015 and 2016 90% of the district's biomedical companies were back at full capacity, with even an increase in production compared to the pre-earthquake situation. Thanks to reconstruction funds, on 10 January 2015 the
Technology Park for Medicine
' (TPM) was inaugurated inside the new Mirandola school complex. This is a scientific-technological park for research into toxicology, proteomics, applied microscopy, cell and material biology, sensors and systems.


District features

More than 300 companies (of which about 100 are medium-sized or large) with a total of almost 4 000 workers are located in the district. Data from the Observatory on the biomedical sector in the Mirandola district for the year 2000 showed a turnover of around 1,000 billion lire and an export quota of around 61%. In 2003, production of disposables reached a value of EUR 475 million, while that of electromedical equipment was EUR 119 million. In 2014, export turnover alone amounted to around 250 million euros. Mirandola Biomedical District is included among the Italian technological districts, thanks to the area's productive specialisation, anyone wishing to undertake an activity in the sector is encouraged to locate within the district. This reduces transport costs and encourages better communication between suppliers and companies in the district. In the case of the biomedical sector, the special feature is the high incidence of exports, a problem that is better addressed when companies are linked. However, as Mirandola is an area of agricultural origin, the organisation of the transport network was not designed for industrial movements: this still causes problems in terms of roads and traffic.


Biomedical museum

The permanent exhibition of Mirandola's biomedical sector (Mobimed), inaugurated at the Castle of the Pico in 2010 and later moved to Via
Odoardo Focherini Odoardo Focherini (sometimes referred to as Edward Focherini; 6 June 1907 – 27 December 1944) was an Italian Roman Catholic Church, Roman Catholic Journalism, journalist. He issued false documents to Jews during World War II in order for them ...
, was set up with the aim of enhancing, preserving and making accessible to everyone the complex of historical and scientific assets of Mirandola's biomedical sector (disposable machines). The intention is to highlight the history and creative/productive capacities of the district since its formation in the mid-1960s. The exhibits boast their origin from the biomedical companies themselves or from private collectors. On display are true rarities, such as the Kiil-type
artificial kidney Artificial kidney is often a synonym for hemodialysis, but may also refer to the other renal replacement therapies (with exclusion of kidney transplantation) that are in use and/or in development. This article deals mainly with bioengineered ki ...
sold by Dasco in the late 1960s. At the entrance, a series of illustrative panels explain the chronology of the birth of all the companies from 1962 to 2012, also providing in-depth information and explanations about the current reality of the biomedical sector (with products and services); there is also a summary of the biography of the founder of biomedical, Mario Veronesi. The last wing of the museum is dedicated to the products/services of local companies, which alternate in the exhibition, displaying their latest medical and scientific innovations.


References


Bibliography

*


See also

*
Biomedical engineering Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to medicine and biology for healthcare purposes (e.g., diagnostic or therapeutic). BME is also traditionally logical sciences ...
*
Pharmaceutical industry The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. ...
*
2012 Northern Italy earthquakes In May 2012, two major earthquakes struck Northern Italy, causing 27 deaths and widespread damage. The events are known in Italy as the 2012 Emilia earthquakes, because they mainly affected the Emilia region. The first earthquake, registering ...
* Santa Maria Bianca Hospital


External links


Comune di Mirandola
1962-2012: 50 anni di Biomedicale
La Plastica della Vita
sul sito la plastica della vita è possibile reperire informazioni sulle aziende e sui progetti del distretto biomedicale di mirandola. La "Plastica Della Vita", che nasce il 23 novembre 2004 come periodico trimestrale. Distribuito nei mesi di gennaio, aprile, luglio e ottobre, si rivolge principalmente agli operatori del distretto biomedicale. La rivista è gratuita e, oltre ad essere presente in tutte le edicole, su richiesta può essere recapitata per posta su richiesta.
Consobiomed
Servizi e promozione per PMI produttrici di dispositivi medici e servizi per il settore biomedicale. *
Storia del Biomedicale a Mirandola
La storia tragica dell'ascesa e caduta dei presidi chirurgici di Mirandola (di Giorgio Goldoni) * {{Cite news, date=2012-06-07, title=Il "distretto biomedicale" su Wikipedia: e i ragazzi di Mirandola vincono il concorso, work=Corriere della Sera, url=http://www.corriere.it/cronache/12_giugno_07/mirandola-studenti-wikipedia-polo-biomedicale_8dd80b60-b0bd-11e1-b62b-59c957015e36.shtml Mirandola Clinical research Companies based in the Province of Modena High-technology business districts