Miles O'Brien may refer to:
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Miles O'Brien (journalist) (born 1959), news journalist
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Miles M. O'Brien (1852–1910), banker and former president of the New York City Board of Education
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Miles O'Brien (''Star Trek''), a fictional character from ''Star Trek: The Next Generation'' and ''Star Trek: Deep Space Nine'', played by Colm Meaney
{{Hndis, Obrien, Miles