Migratory aptitude is the relative ability of a migrating group to migrate in a
rearrangement reaction
In organic chemistry, a rearrangement reaction is a broad class of organic reactions where the carbon skeleton of a molecule is rearranged to give a structural isomer of the original molecule. Often a substituent moves from one atom to another ...
.
Migratory aptitudes vary in different reactions, depending on multiple factors.
In the
Baeyer-Villiger reaction, the more substituted group, in general, migrates.
In the
pinacol rearrangement
The pinacol–pinacolone rearrangement is a method for converting a 1,2-diol to a carbonyl compound in organic chemistry. The 1,2-rearrangement takes place under acidic conditions. The name of the rearrangement reaction comes from the rearrangemen ...
, the order of migratory aptitude has not been determined unambiguously,
[ but some trends have been determined. For example, relative migratory aptitudes for alkyl substituents is Hydride >Phenide>C(CH3)3> C2H5 > CH3.][
]
References
Organic chemistry
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