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The Microbicide Trials Network (MTN, 2006-2021) was a United States government-funded research organization working in the field of
microbicides for sexually transmitted diseases Microbicides for sexually transmitted diseases are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause human infection (for example, the human immunodeficiency virus) ...
. The MTN focused on research into microbicides which would prevent
HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...
infection. The MTN was a member of
HANC Hanc is a village and former commune in the Deux-Sèvres department in western France. On 1 January 2019, it was merged into the new commune Valdelaume.
. After its closure, partner organization HIV Prevention Trials Network took control of its projects.


Research

The MTN's notable research included various
clinical trials Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...
. The results of the
CAPRISA 004 CAPRISA 004 is the name of a clinical trial conducted by CAPRISA. This particular study was the first to show that a topical gel could reduce a person's risk of contracting HIV. The gel used in the study contained a microbicide. Background A pr ...
trial inspired the research of the MTN and the microbicide field. The Vaginal and Oral Interventions to Control the Epidemic (VOICE) found a vaginal gel containing an anti-HIV drug to be ineffective at preventing HIV transmission.. The HOPE study tested
dapivirine Dapivirine is a non-nucleoside reverse transcriptase inhibitor developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership for Microbicides has held exclusive worldwide rights to dapivirine since 2014, buildin ...
vaginal rings for HIV prevention in 1,456 study participants at 14 sites in Malawi, South Africa, Uganda and Zimbabwe.


References


External links

* {{Microbicides for sexually transmitted diseases HIV/AIDS organizations in the United States Medical and health organizations based in Pennsylvania Microbicides Defunct organizations based in the United States