Michel Macheboeuf (19 October 1900 – 20 August 1953) was a French physician scientist who served as a head of the biochemistry department of the

Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines f ...

and studied blood lipids. He has been called the father of plasma lipoproteins. Macheboeuf was born in

Châtel-Guyon Châtel-Guyon (; oc, label=Auvergnat, Chastel Guion) is a commune in the Puy-de-Dôme department in Auvergne-Rhône-Alpes in central France. Prior to June 2008 it was known as Châtelguyon.Clermont-Ferrand Clermont-Ferrand (, ; ; oc, label=Auvergnat (dialect), Auvergnat, Clarmont-Ferrand or Clharmou ; la, Augustonemetum) is a city and Communes of France, commune of France, in the Auvergne-Rhône-Alpes regions of France, region, with a population ...

and Paris, he joined Gabriel Bertrand’s laboratory at the Pasteur Institute. He also studied with S.P.L. Sørensen in Copenhagen as a Rockefeller Fellow. Along with Bertrand, he found lipids in blood plasma and they found that they could be complexed with albumin (he called it as "cenapse"). The principle is still used in the lipid albumin index used in clinical studies, which is the amount of lipid that remains water-soluble after addition of albumin. Im 1929 he isolated lipoprotein by precipitating using a neutral 50% ammonium sulfate extract of serum and then lowering the pH to 3.8. Macheboeuf also studied tuberculosis and examined the effect of high pressure on bacteria and viruses. He married Simone Bezou and they had three daughters. He died from a lung infection.

References

{{DEFAULTSORT:Macheboeuf, Michel 1900 births 1953 deaths French biochemists