Michaelis–Gutmann bodies (M-G bodies) are concentrically layered
basophilic inclusions found in
Hansemann cells in the
urinary tract. These are 2 to 10 μm in diameter, and are thought to represent remnants of
phagosomes mineralized by
iron
Iron is a chemical element; it has symbol Fe () and atomic number 26. It is a metal that belongs to the first transition series and group 8 of the periodic table. It is, by mass, the most common element on Earth, forming much of Earth's o ...
and
calcium deposits.
M-G bodies are a
pathognomonic
Pathognomonic (synonym ''pathognomic'') is a term, often used in medicine, that means "characteristic for a particular disease". A pathognomonic sign is a particular sign whose presence means that a particular disease is present beyond any doubt. ...
feature of
malakoplakia, an inflammatory condition that affects the
genitourinary tract. They were initially discovered in 1902 by
Leonor Michaelis and Carl Gutmann.
Michaelis-Gutmann bodies stain positive for
von kossa (calcium),
Prussian Blue (iron), and
PAS diastase stain.
References
University of Chicago; Emerging Infections* https://www.pathologyoutlines.com/topic/bladdermalakoplakia.html
Urinary system
{{genitourinary-stub