Mibefradil (trade name Posicor) was a

pharmaceutical drug A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...

used for the treatment of

hypertension Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...

and chronic angina pectoris. It is a nonselective

calcium channel blocker Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as ...

. It was voluntary pulled from the market ten months after FDA approval, citing potential serious health hazards shown in post release studies. The mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (

T-type The T-Type name was used in a series of Buick automobiles that were popular during the 1980s. This marketing approach for Buick products was a revival of a similar approach used in the 1960s (and later revived in the 1990s) with the Buick GS de ...

) calcium channels over long-lasting, high-voltage-activated ( L-type) calcium channels, which is probably responsible for many of its unique properties. On June 8, 1998,

Roche F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX S ...

announced the voluntary withdrawal of the drug from the market, one year after approval by the FDA, due to the potential for drug interactions, some of them deadly, which may occur when it is taken together with some other medications.

Synthesis

References

Amines Benzimidazoles Calcium channel blockers CYP2D6 inhibitors CYP3A4 inhibitors Ethers Isopropyl compounds Fluoroarenes Tetralins Withdrawn drugs {{cardiovascular-drug-stub