Metodesnitazene
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Metodesnitazene (also known as Metazene) is a
benzimidazole Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a colorless solid. Preparation Benzimidazole is produced by condensation of o- ...
derivative with
opioid Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid us ...
effects, though unlike related compounds such as
metonitazene Metonitazene is an analgesic compound related to etonitazene, which was first reported in 1957, and has been shown to have approximately 100 times the potency of morphine by central routes of administration, but if used orally it has been shown t ...
and
etodesnitazene Etodesnitazene (Desnitroetonitazene, Etazen, Etazene, Etazone) is a benzimidazole derived opioid analgesic drug, which was originally developed in the late 1950s alongside etonitazene and a range of related derivatives. It is many times less pote ...
which are many times more potent, metodesnitazene is only around the same potency as
morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a analgesic, pain medication, and is also commonly used recreational drug, recreationally, or to make ...
in animal studies. It was proposed by the DEA to be placed under legal control in the US in December 2021.


See also

*
Etonitazepyne Etonitazepyne (N-Pyrrolidino Etonitazene) is a benzimidazole derivative with potent opioid effects which has been sold over the internet as a designer drug and linked to numerous cases of overdose. See also * Etazene * Etonitazepipne * Isoto ...
*
Isotonitazene Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as ...
*
List of benzimidazole opioids Benzimidazole opioids, also known as nitazenes, are a class of synthetic opioids with an unusual benzimidazole structure often referred to as opioid New Psychoactive Substances (opioid NPS). First synthesized in the 1950s by CIBA Pharmaceuticals ...


References

Analgesics Designer drugs Opioids Benzimidazoles Aromatic ethers {{Analgesic-stub