Methylphosphinic acid is a monobasic acid, the simplest of the

phosphinic acid Hypophosphorous acid (HPA), or phosphinic acid, is a phosphorus oxyacid and a powerful reducing agent with molecular formula H3PO2. It is a colorless low-melting compound, which is soluble in water, dioxane and alcohols. The formula for this ...

s. A central phosphorus atom is connected to a hydroxy group, a hydrogen atom, a methyl group and an oxygen. Derivatives of methylphosphinic acid can have the phosphorus connected hydrogen atom replaced by other organic groups. In early days what is now called methylphosphonic acid was also called methylphosphinic acid.

Production

Methylphosphinic acid can be produced by the hydrolysis of dimethyl methylphosphonate, which is conveniently obtained from

trimethylphosphite Trimethyl phosphite is an organophosphorus compound with the formula P(OCH3)3, often abbreviated P(OMe)3. It is a colorless liquid with a highly pungent odor. It is the simplest phosphite ester and finds used as a ligand in organometallic che ...

. Hydrolysis of

methyldichlorophosphine Methyldichlorophosphine (alternatively known as dichloro(methyl)phosphane and methyl phosphonous dichloride) is an organophosphorus compound with the chemical formula CH3PCl2. It is a colorless, corrosive, flammable, and highly reactive liquid wit ...

yields methylphosphinic acid, Methylphosphinic acid is a common byproduct of the hydrolysis of various CH₃P-containing esters and amides, as occur in pesticides for example.

Properties

Rat oral value for methylphosphinic acid is 940 mg/kg.

Derivatives

* (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid TPMPA *N-methylaminomethane-P-methylphosphinic acid or N-methylamino-methyl-methylphosphinic acid *Ethane-1,2-diylbis(methylphosphinic acid) *(3-amino-2-hydroxypropyl)methylphosphinic acid *Methylphosphinic acid ethyl ester (CAS number 16391-07-4) *dimethylphosphoryloxy-methylphosphinic acid * N,N-dimethylaminomethane-P-methylphosphinic acid *(Aminomethyl)methylphosphinic acid 15901-11-8 *(2-aminobenzyl)-methylphosphinic acid *(6-amino-3-ethyl-1H-benzimidazol-3-ium-2-yl)-methylphosphinic acid * 2S,3S)-3-(methoxymethyl)pentan-2-ylxy-methylphosphinic acid *(3-Aminocyclopentyl)methylphosphinic acid *methylene-di(methylphosphinic acid)

References

{{Reflist Phosphinic acids Organic compounds with 1 carbon atom