3-Methoxyeticyclidine (3-MeO-PCE), also known as methoxieticyclidine,
is a
dissociative anesthetic that is qualitatively similar to
PCE and
PCP and has been sold online as a
designer drug.
On October 18, 2012 the
Advisory Council on the Misuse of Drugs in the
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and North ...
released a report about
methoxetamine, saying that the "harms of methoxetamine are commensurate with
Class B of the
Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of methoxetamine should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-MeO-PCE.
This report also described the receptor binding profile of methoxetamine and three additional dissociatives
3-MeO-PCP
3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative hallucinogen of the arylcyclohexylamine class related to phencyclidine (PCP) which has been sold online as a designer drug. It acts mainly as an NMDA receptor antagonist, though it has also bee ...
,
4-MeO-PCP
4-Methoxyphencyclidine (methoxydine, 4-MeO-PCP) is a dissociative anesthetic drug that has been sold online as a research chemical. The synthesis of 4-MeO-PCP was first reported in 1965 by the Parke-Davis medicinal chemist Victor Maddox. A 1999 ...
, and 3-MeO-PCE, showing them to have significant affinity for the PCP site of the
NMDA receptor
The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA rece ...
(NMDAR) and was later published in more detail.
3-MeO-PCE has
Ki values of 61 nM for the NMDAR, 743 nM for the
dopamine transporter, 2097 nM for the
histamine H2 receptor, 964 nM for the
alpha-2A adrenergic receptor, 115 nM for the
serotonin transporter, 4519 nM for the
σ1 receptor, and 525 nM for the
σ2 receptor.
Legal status
3-MeO-PCE is banned in Sweden and Switzerland.
As per Chile's
Ley de drogas, aka Ley 20000,
all esters and ethers of PCE are illegal. As 3-MeO-PCE is an
ether
In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be c ...
of PCE, it is thus illegal.
See also
*
3-HO-PCP
3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative of the arylcyclohexylamine class related to phencyclidine (PCP) that has been sold online as a designer drug.
Pharmacology
3-HO-PCP acts as a high-affinity uncompetitive antagonist of the NMD ...
*
3-MeO-PCMo
3-MeO-PCMo is a dissociative anesthetic drug which is similar in structure to phencyclidine and been sold online as a designer drug. The inhibitory effect of 3-MeO-PCMo on the reduction in the density of the drebrin clusters by NMDAR stimulation ...
*
Arylcyclohexylamine
*
Ketamine
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ne ...
*
Methoxyketamine
*
Eticyclidine
References
{{Sigma receptor modulators
Arylcyclohexylamines
Dissociative drugs
O-methylated phenols
Designer drugs