Metanephric dysplastic hematoma of the sacral region (MDHSR) has been described by Cozzutto and Lazzaroni-Fossati in 1980, by Posalaki et al. in 1981 and by Cozzutto et al. in 1982. Three additional cases were seen by Finegold.

Case studies

The case reported by Cozzutto and Lazzaroni-Fossati involved a premature male newborn with bilateral renal

dysplasia Dysplasia is any of various types of abnormal growth or development of cells (microscopic scale) or organs ( macroscopic scale), and the abnormal histology or anatomical structure(s) resulting from such growth. Dysplasias on a mainly microscopi ...

and a sacrococcygeal mass featuring a histological picture of renal dysplasia. The case reported by Cozzutto et al. and those studied by Finegold featured changes of renal dysplasia including immature tubules surrounded by a collarette of cellular mesenchyme, glomeruloid figures, tubules and nests of cartilage in a background of

adipose tissue Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular ...

and fibrous tissue where muscle fibres, nerve bundles and calcospherites were also seen. The two cases reported by Posalaki et al. showed blastema,

glomeruli ''Glomerulus'' () is a common term used in anatomy to describe globular structures of entwined vessels, fibers, or neurons. ''Glomerulus'' is the diminutive of the Latin ''glomus'', meaning "ball of yarn". ''Glomerulus'' may refer to: * the filter ...

and tubuli. In several cases the mass was removed during reparative surgery for

meningocele Spina bifida (Latin for 'split spine'; SB) is a birth defect in which there is incomplete closing of the spine and the membranes around the spinal cord during early development in pregnancy. There are three main types: spina bifida occulta, men ...

myelomeningocele Spina bifida (Latin for 'split spine'; SB) is a birth defect in which there is incomplete closing of the spine and the membranes around the spinal cord during early development in pregnancy. There are three main types: spina bifida occulta, men ...

. Alston et al. described immature renal tissue in a lumbosacral subcutaneous

lipoma A lipoma is a benign tumor made of fat tissue. They are generally soft to the touch, movable, and painless. They usually occur just under the skin, but occasionally may be deeper. Most are less than in size. Common locations include upper back, ...

with intradural extension in a 6-day-old female. Horestein et al. reported a lumbosacral nephrogenic rest including blastema (mature tubules and nephrons) in abundant stroma unassociated to

spinal dysraphism Neural tube defects (NTDs) are a group of birth defects in which an opening in the spine or cranium remains from early in human development. In the third week of pregnancy called gastrulation, specialized cells on the dorsal side of the embry ...

. The case reported by Ibrahim et al. in a 2-year-old boy comprised adipose and fibrous tissue with

neuroglial Glia, also called glial cells (gliocytes) or neuroglia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system that do not produce electrical impulses. They maintain homeostasis, form mye ...

elements, striated muscle fibres and clusters of glomeruloid structures and immature tubules. Sacrococcygeal

teratoma A teratoma is a tumor made up of several different types of tissue, such as hair, muscle, teeth, or bone. Teratomata typically form in the ovary, testicle, or coccyx. Symptoms Symptoms may be minimal if the tumor is small. A testicular ter ...

with

nephroblastoma Wilms' tumor or Wilms tumor, also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children, rarely in adults.; and occurs most commonly as a renal tumor in child patients. It is named after Max Wilms, the German surg ...

was reported by Ward and Dehner and by Trebbi et al. Cases of primary lumbosacral

Wilms tumor Wilms' tumor or Wilms tumor, also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children, rarely in adults.; and occurs most commonly as a renal tumor in child patients. It is named after Max Wilms, the German ...

were described by Abrahams et al. and by Govender et al.,.Govender D, Hadley GP, Nadvi SS, Donnellan RB (2000) Primary lumbosacral Wilms tumor with occult dysraphism. Virchows Arch 436:502-505 It is therefore of primary importance the distinction of MDHSR from sacrococcygeal teratoma and from primary lumbosacral Wilms tumor.

References

{{Reflist Vascular diseases