Maximilian (Max) Ruppert Franz von Frey (16 November 1852 – 25 January 1932) was an Austrian-German
physiologist
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...
who was born in
Salzburg
Salzburg (, ; literally "Salt-Castle"; bar, Soizbuag, label=Bavarian language, Austro-Bavarian) is the List of cities and towns in Austria, fourth-largest city in Austria. In 2020, it had a population of 156,872.
The town is on the site of the ...
.
He received his doctorate from the
University of Leipzig
Leipzig University (german: Universität Leipzig), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 Decemb ...
in 1877, and subsequently worked at
Carl Ludwig
Carl Friedrich Wilhelm Ludwig (; 29 December 1816 – 23 April 1895) was a German physician and physiologist. His work as both a researcher and teacher had a major influence on the understanding, methods and apparatus used in almost all branches ...
's Physiological Institute in
Leipzig
Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...
. Later he was a professor of
physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
at the Universities of
Würzburg
Würzburg (; Main-Franconian: ) is a city in the region of Franconia in the north of the German state of Bavaria. Würzburg is the administrative seat of the ''Regierungsbezirk'' Lower Franconia. It spans the banks of the Main River.
Würzburg is ...
and
Zurich.
Frey's primary work in Leipzig dealt with the
circulatory system
The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...
, and he is credited with developing an early prototype of a heart-lung machine.
He is remembered for his work involving
cutaneous
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation.
Other animal coverings, such as the arthropod exoskeleton, have different de ...
sensory
mechanoreceptor
A mechanoreceptor, also called mechanoceptor, is a sensory receptor that responds to mechanical pressure or distortion. Mechanoreceptors are innervated by sensory neurons that convert mechanical pressure into electrical signals that, in animals, ...
s. During the 1890s, Frey proposed that pain is an independent tactile quality, alongside touch, heat and cold, and that it is associated with stimulation of high-threshold
free nerve ending
A free nerve ending (FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron. ''Afferent'' in this case means bringing information from the body's periphery toward the brain. They function as cu ...
s. He described the skin as a mosaic of discrete spots, each sensitive to one or another of these stimuli.
He created a unique type of
esthesiometer
An esthesiometer (British spelling aesthesiometer) is a device for measuring the tactile sensitivity of the skin (or mouth, or eye, etc.). The measure of the degree of tactile sensitivity is called aesthesiometry. The device was invented by Edwar ...
, now referred to as a
von Frey hair
An esthesiometer (British spelling aesthesiometer) is a device for measuring the tactile sensitivity of the skin (or mouth, or eye, etc.). The measure of the degree of tactile sensitivity is called aesthesiometry. The device was invented by Edwar ...
, which consisted of various calibrated
monofilaments. These filaments can be used to determine the threshold force required to produce the sensation of touch or pain.
References
External links
UCLA LibraryPioneer Neurophysiology
Essay on Sensory LocationsVon Frey Hair AesthesiometerVon Frey Aesthesiometer
{{DEFAULTSORT:Frey, Maximilian von
1852 births
1932 deaths
German physiologists
Physicians from Salzburg
Academic staff of the University of Würzburg
Academic staff of the University of Zurich