Mauro Ferrari
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Mauro Ferrari (born 7 July 1959) is a nanoscientist and leader in the field of
nanomedicine Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and BioBrick, biological devices, to Nanoelectronics, nanoelectronic biosensors, and even possible future applicatio ...
. He served as special expert on nanotechnology for the
National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...
(2003-2005) and was instrumental in establishing the Alliance for Nanotechnology in Cancer in 2004. On 1 January 2020, Ferrari was made president of the
European Research Council The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...
(ERC).Commission appoints Mauro Ferrari as next President of the European Research Council
European Commission The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body o ...
, press release of 14 May 2020.
Following a vote of no confidence, on 27 March 2020, "all 19 active members of the ERC’s Scientific Council individually and unanimously requested that Mauro Ferrari resign from his position as ERC’s President", due to poor conduct in office, exploiting the position to further his own projects, and for consistently failing to represent the interests of the ERC.Resignation of Mauro Ferrari – Statement by the Scientific Council
European Commission The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body o ...
, ERC press release of 8 April 2020.
On 7 April 2020, Ferrari officially resigned, stating to the media that he was "extremely disappointed by the European response” to the pandemic and expressing frustration over opposition to his efforts to launch a scientific program to combat the virus.


Early life and education

Ferrari was born in
Padova Padua ( ; it, Padova ; vec, Pàdova) is a city and ''comune'' in Veneto, northern Italy. Padua is on the river Bacchiglione, west of Venice. It is the capital of the province of Padua. It is also the economic and communications hub of the ...
, Italy in 1959. He spent his early years in Udine and Florence before attending the University of Padova and earning his Laurea in Mathematics in 1985. He moved to Berkeley, California where he earned his master's and doctorate in mechanical engineering from the University of California Berkeley.


Career


Professor of Engineering

Ferrari became an associate professor of engineering at Berkeley, then moved to the
Ohio State University The Ohio State University, commonly called Ohio State or OSU, is a public land-grant research university in Columbus, Ohio. A member of the University System of Ohio, it has been ranked by major institutional rankings among the best publ ...
as professor of bioengineering, internal medicine, and mechanical engineering. He studied medicine at the
Ohio State University The Ohio State University, commonly called Ohio State or OSU, is a public land-grant research university in Columbus, Ohio. A member of the University System of Ohio, it has been ranked by major institutional rankings among the best publ ...
concurrent with his faculty appointment from 2002-2004.


Cancer research

He moved to the
MD Anderson Cancer Center The University of Texas MD Anderson Cancer Center (colloquially MD Anderson Cancer Center) is a comprehensive cancer center in Houston, Texas. It is the largest cancer center in the U.S. and one of the original three comprehensive cancer centers ...
and
University of Texas Health Science Center The University of Texas System (UT System) is an American government entity of the state of Texas that includes 13 higher educational institutions throughout the state including eight universities and five independent health institutions. The UT& ...
at Houston, TX to become the chair of the department of nanomedicine and biomedical engineering, and then in 2010 accepted the position of president and CEO of the
Houston Methodist Research Institute Houston Methodist Hospital is the flagship quaternary care hospital of Houston Methodist academic medical center. Located in the Texas Medical Center in Houston, Texas, Houston Methodist Hospital was established in 1919 during the height of the ...
in Houston, TX. Ferrari was appointed as Chief Commercialization Officer of Houston Methodist in 2018, and retired in 2019.


ERC President (2020)

In 2019, the
European Commission The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body o ...
appointed Ferrari as the next President of the
European Research Council The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...
(ERC), succeeding
Jean-Pierre Bourguignon Jean-Pierre Bourguignon (born 21 July 1947) is a French mathematician, working in the field of differential geometry. Biography Born in Lyon, he studied at École Polytechnique in Palaiseau, graduating in 1969. For his graduate studies he went t ...
; he was selected by a search committee chaired by
Mario Monti Mario Monti, (born 19 March 1943) is an Italian economist and academic who served as the Prime Minister of Italy from 2011 to 2013, leading a technocratic government in the wake of the Italian debt crisis. Monti served as a European Commiss ...
. He took the post on 1 January 2020. Ferrari resigned in 7 April 2020, citing his disappointment at the lack of coordinated EU action to address the
COVID-19 pandemic The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identif ...
. Ferrari was not alone in his criticism of the EU response to COVID-19. The ERC countered that calling for specific research was contrary to their mandate. According to ''Science Magazine'', "ERC, set up to reward bottom-up basic research ideas, does not designate money for specific research areas....Other EU organ zation can and do pay for research in particular fields, including COVID-19, but ERC is designed to protect science from politics. Ferrari writes that 'the expected burden of death, suffering, societal transformation, and economic devastation' of the pandemic justifies breaking this rule." The ERC responded on 8 April 2020: "...we regret Professor Ferrari's statement, which at best is economical with the truth." The ERC stated that Ferrari's "resignation in fact followed a written unanimous vote of no confidence”. They cited "a complete lack of appreciation for the raison-d’être of the ERC", "a lack of engagement with the ERC", with Ferrari "failing to participate in many important meetings, spending extensive time in the USA and failing to defend the ERC’s programme and mission," making "several personal initiatives within the Commission" without consulting the ERC, and being "involved in multiple external enterprises, some academic and some commercial, which took a lot of his time and effort and appeared on several occasions to take precedence over his commitment to ERC." Ferrari disputed the ERC claims of his failing to meet his obligations and their accusations of inappropriate outside involvements. In the months following Ferrari's resignation, the EU itself debated whether some funding of the ERC should include some focused research on COVID-19; which is what Ferrari advocated and the ERC adamantly opposed.


Other activities


Corporate boards

* AMBER, Member of the Scientific Advisory Board *
Arrowhead Pharmaceuticals Arrowhead Pharmaceuticals is a publicly traded biopharmaceutical company based in Pasadena, California. Arrowhead’s products in development act through RNA interference (RNAi) mechanisms of action. The company focuses on treatments for hepatiti ...
, Member of the Board of Directors (2010–present) * Dead Sea Research Institute, President of the int'l board of governors * Leonardo Biosystems, Member of the Board of Directors * NanoMedical Systems, Member of the Board of Directors


Non-profit organizations

* Member of the Engineering Leadership Board,
Cullen College of Engineering Cullen may refer to: Places Canada *Cullen, Saskatchewan, a former hamlet in Benson No. 35 Rural Municipality Ireland *Cullen, County Cork, a village near Boherbue, County Cork *Cullen, County Tipperary, a small village in County Tipperary Scotl ...
,
University of Houston The University of Houston (UH) is a Public university, public research university in Houston, Texas. Founded in 1927, UH is a member of the University of Houston System and the List of universities in Texas by enrollment, university in Texas ...


Research interests

Ferrari's research uses
nanotechnology Nanotechnology, also shortened to nanotech, is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The earliest, widespread description of nanotechnology referred to the particular technological goal o ...
,
microtechnology Microtechnology deals with technology whose features have dimensions of the order of one micrometre (one millionth of a metre, or 10−6 metre, or 1μm). It focuses on physical and chemical processes as well as the production or manipulation of str ...
, physical sciences,
mathematics Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics ...
,
biomechanics Biomechanics is the study of the structure, function and motion of the mechanical aspects of biological systems, at any level from whole organisms to organs, cells and cell organelles, using the methods of mechanics. Biomechanics is a branch of ...
, and material sciences to develop new technologies for health care applications like
drug delivery Drug delivery refers to approaches, formulations, manufacturing techniques, storage systems, and technologies involved in transporting a pharmaceutical compound to its target site to achieve a desired therapeutic effect. Principles related to d ...
and
cancer therapeutics Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bl ...
. He leads a physical sciences in
oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ó ...
center, one of a network of centers sponsored by the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
National Cancer Center National Cancer Center ("NCC" or "Center"), founded in 1953, is a (501)(c)(3) not-for-profit organization in the United States that funds young cancer researchers who are working to discover how the body's immune system sees and responds to ca ...
. The research of this center focuses on understanding the physical and biomechanical
biological Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary in ...
barriers that reduce the efficacy of cancer therapeutics. He developed a new drug called iNPG-pDox, composed of
silicon Silicon is a chemical element with the symbol Si and atomic number 14. It is a hard, brittle crystalline solid with a blue-grey metallic luster, and is a tetravalent metalloid and semiconductor. It is a member of group 14 in the periodic tab ...
nanoparticle A nanoparticle or ultrafine particle is usually defined as a particle of matter that is between 1 and 100 nanometres (nm) in diameter. The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 1 ...
s loaded with
polymer A polymer (; Greek '' poly-'', "many" + ''-mer'', "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic a ...
ic
doxorubicin Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used togeth ...
, that had better results at lower doses in animal models compared to standard
doxorubicin Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used togeth ...
chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...
for
metastatic Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, ...
breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...
.


Published works

Ferrari has produced more than 350 publications, including seven books and 41 issued patents in the US and Europe. In June 2020, Ferrari and his lab colleagues had a publication retracted from Science Advances Journal due to various image duplications suggesting possible scientific misconduct.


Books

* Ferrari M, Granik VT, Imam A, Nadeau J, editors. Advances in Doublet Mechanics. Lecture Notes in Physics, New Series M: Monographs, vol. m 45. Berlin, Heidelberg, New York: Springer Verlag; 1997. * Ferrari M. Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications. SPIE, The International Society for Optical Engineering; 1999 Jan. * Lee A, Lee J, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol I: Biological and Biomedical Nanotechnology. Springer. 2006. * Ozkan M, Heller M, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol II: Micro/Nanotechnologies for Genomics and Proteomics. Springer. 2006. * Desai T, Bhatia SN, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol III: Therapeutic Micro/Nanotechnologies. Springer. 2006. * Bashir R, Werely S, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol IV: Biomolecular Sensing, Processing, and Analysis. Springer. 2006. * Cristini V, Ferrari M, Decuzzi P, editors. Nanoparticulate Delivery to Cancerous Lesions: Advances in Mathematical Modeling. Ferrari M, series editor. Fundamental Biomedical Technologies. Vol. 2. Springer. April 2010.


Journal articles

* * * * * * * * * * * * * * * * * * *


Patents

* * * * * * * * * * * * * * * * * * * * * * *


Honors, decorations, awards and distinctions

* 2008 Fellow,
American Institute for Medical and Biological Engineering The American Institute for Medical and Biological Engineering (AIMBE) is a non-profit organization founded in 1991, and headquartered in Washington. It represents 50,000 medical and biomedical engineers, and academic institutions, private industry, ...
* 2009 Fellow,
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
* 2011 Founders Award,
Controlled Release Society Control may refer to: Basic meanings Economics and business * Control (management), an element of management * Control, an element of management accounting * Comptroller (or controller), a senior financial officer in an organization * Controlling ...
* 2015 Aurel Stodola Medal, Mechanical Engineering, ETH Zurich, Switzerland


Personal life

Ferrari met and married his first wife Marialuisa while they were both students at the University of Padova, and they moved to Berkeley, California. While he was faculty at the
University of California Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant univ ...
, Marialuisa died from cancer. Ferrari married Paola Del Zotto from Udine, Italy in 1995. He has five children, including two sets of twins.


References

{{DEFAULTSORT:Ferrari, Mauro 1959 births Living people Scientists from Padua Cornell University faculty University of California, Berkeley alumni COVID-19 pandemic in Italy