Mauricio Tohen is a Mexican American research psychiatrist,

Distinguished Professor Professors in the United States commonly occupy any of several positions of teaching and research within a college or university. In the U.S., the word "professor" informally refers collectively to the Academic ranks in the United States, academ ...

, and

Chairman The chairperson, also chairman, chairwoman or chair, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the grou ...

of the Department of

Psychiatry Psychiatry is the medical specialty devoted to the diagnosis, prevention, and treatment of mental disorders. These include various maladaptations related to mood, behaviour, cognition, and perceptions. See glossary of psychiatry. Initial psych ...

Behavioral Sciences Behavioral sciences explore the cognitive processes within organisms and the behavioral interactions between organisms in the natural world. It involves the systematic analysis and investigation of human and animal behavior through naturalistic o ...

at the

University of New Mexico The University of New Mexico (UNM; es, Universidad de Nuevo México) is a public research university in Albuquerque, New Mexico. Founded in 1889, it is the state's flagship academic institution and the largest by enrollment, with over 25,400 ...

. Tohen's research has focused on the epidemiology, outcome, and treatment of bipolar and psychotic disorders, and is especially known for innovating the design of

clinical trials Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

and the criteria to determine outcome in such diseases. Tohen has edited several books on his specialties. His social awareness has been noted in the promotion of programs to improve mental health care in areas such as substance abuse, bipolar disorder and schizophrenia.

Education

Tohen graduated as an MD from the

National Autonomous University of Mexico The National Autonomous University of Mexico ( es, Universidad Nacional Autónoma de México, UNAM) is a public research university in Mexico. It is consistently ranked as one of the best universities in Latin America, where it's also the bigges ...

, Mexico City in 1976. He trained in Psychiatry at the

University of Toronto The University of Toronto (UToronto or U of T) is a public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution ...

where he also obtained a DPsych Diploma in Psychiatric Research (1979–1982). He then pursued a fellowship in

Psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on m ...

(1982–1985) at

McLean Hospital McLean Hospital () (formerly known as Somerville Asylum and Charlestown Asylum) is a psychiatric hospital in Belmont, Massachusetts. It is noted for its clinical staff expertise and neuroscience research and is also known for the large number of ...

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

, followed by a Doctorate in

public health Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the det ...

(epidemiology) completed in 1988 at

Harvard School of Public Health The Harvard T.H. Chan School of Public Health is the public health school of Harvard University, located in the Longwood Medical Area of Boston, Massachusetts. The school grew out of the Harvard-MIT School for Health Officers, the nation's first ...

. In 2000, Tohen also obtained an

MBA A Master of Business Administration (MBA; also Master's in Business Administration) is a postgraduate degree focused on business administration. The core courses in an MBA program cover various areas of business administration such as accounti ...

degree from the

Kelley School of Business The Kelley School of Business (KSB) is an undergraduate and graduate business school at Indiana University in Bloomington, Indiana and Indianapolis, Indiana, United States. , approximately 7,500 full-time undergraduate and graduate students are ...

Indiana University Indiana University (IU) is a system of public universities in the U.S. state of Indiana. Campuses Indiana University has two core campuses, five regional campuses, and two regional centers under the administration of IUPUI. *Indiana Universit ...

Career

Tohen´s career has developed both in academia and industry.

Academia

Tohen spent the first decade of his academic career (1999–2009) at

Harvard Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

where he was 1) Associate Professor of Epidemiology at Harvard School of Public Health, teaching Psychiatric Epidemiology, 2) Clinical Director of the Bipolar and Psychotic Disorders Program at McLean Hospital, conducting research on bipolar disorder and first-episode psychosis, and 3) AssociateProfessor of Psychiatry at Harvard Medical School. Tohen worked at the

University of Texas Health Science Center at San Antonio The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is a public academic health science center in San Antonio, Texas. It is part of the University of Texas System. UT Health San Antonio is the largest health scie ...

, at the Department of Psychiatry where he occupied positions as Division Head of Mood & Anxiety Disorders, Aaron & Bobbie Elliott Krus Endowed Chair, and tenured Professor. Since 2013, Tohen has been a Professor and Chairman of the Department of Psychiatry & Behavioral Sciences at The University of New Mexico, Health Sciences Center (Albuquerque, NM), where in 2020 he was promoted to the category of

Distinguished Professor Distinguished Professor is an academic title given to some top tenured professors in a university, school, or department. Some distinguished professors may have endowed chairs. In the United States Often specific to one institution, titles such ...

Industry

From 1997 to 2012, Tohen joined

Lilly Research Laboratories Eli Lilly and Company is an American pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by, and named after, Colonel ...

in Indianapolis, where he reached the position of Distinguished Lilly Scholar. Based on his leadership and clinical trial design, the company obtained the indication for

Olanzapine Olanzapine (sold under the trade name Zyprexa among others) is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. For schizophrenia, it can be used for both new-onset disease and long-term maintenance. It is ta ...

for the treatment of Acute Mania and relapse prevention from the

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

and the European CPMP, as well as the indication for bipolar depression for fluoxeinte/olanzapine combination from the FDA, and the indication of Olanzapine for acute mania and bipolar depression from the PMDA in Japan.

Research

Tohen has authored over 380 original publications with over 40,000 scientific citations. His most cited papers include: * Hegarty, J. D.; Baldessarini, R. J.; Tohen, M.; Waternaux, C.; Oepen, G. (October 1994). "One hundred years of schizophrenia: a meta-analysis of the outcome literature". ''The American Journal of Psychiatry''. 151 (10): 1409–1416. doi:10.1176/ajp.151.10.1409.

ISSN An International Standard Serial Number (ISSN) is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs ...

0002-953X.

PMID PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the ...

8092334. * Tohen, M.; Sanger, T. M.; McElroy, S. L.; Tollefson, G. D.; Chengappa, K. N.; Daniel, D. G.; Petty, F.; Centorrino, F.; Wang, R.; Grundy, S. L.; Greaney, M. G. (May 1999). "Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group". ''The American Journal of Psychiatry''. 156 (5): 702–709. doi:10.1176/ajp.156.5.702.

0002-953X.

10327902. * Tohen, Mauricio; Vieta, Eduard; Calabrese, Joseph; Ketter, Terence A.; Sachs, Gary; Bowden, Charles; Mitchell, Philip B.; Centorrino, Franca; Risser, Richard; Baker, Robert W.; Evans, Angela R. (2003-11). "Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression". ''Archives of General Psychiatry''. 60 (11): 1079–1088. doi:10.1001/archpsyc.60.11.1079.

0003-990X.

14609883 *Tohen, M.; Jacobs, T. G.; Grundy, S. L.; McElroy, S. L.; Banov, M. C.; Janicak, P. G.; Sanger, T.; Risser, R.; Zhang, F.; Toma, V.; Francis, J. (2000-09). "Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group". ''Archives of General Psychiatry''. 57 (9): 841–849. doi:10.1001/archpsyc.57.9.841.

0003-990X.

10986547

Research topics

Research articles where Tohen is an author will be found in current entries on

Antipsychotic Antipsychotics, also known as neuroleptics, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but ...

, Associated features of bipolar disorder,

Atypical antipsychotic The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and ne ...

Bipolar disorder Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that last from days to weeks each. If the elevated mood is severe or associated with ...

Bipolar I disorder Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features. Most people also, at other time ...

Cariprazine Cariprazine, sold under the brand names Vraylar and Reagila among others, is an on oral atypical antipsychotic originated by Gedeon Richter, which is used in the treatment of schizophrenia, bipolar mania, and bipolar depression. It acts prim ...

Clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

Early intervention in psychosis Early intervention in psychosis is a clinical approach to those experiencing symptoms of psychosis for the first time. It forms part of a new prevention paradigm for psychiatry and is leading to reform of mental health services, especially in th ...

Lurasidone Lurasidone, sold under the trade name Latuda among others, is an antipsychotic medication used to treat schizophrenia and bipolar disorder. It is taken by mouth. Common side effects include sleepiness, movement disorders, nausea, and diarrhea. ...

Mental disorder A mental disorder, also referred to as a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. Such features may be persistent, relapsing and remitti ...

Mixed affective state A mixed affective state, formerly known as a mixed-manic or mixed episode, has been defined as a state wherein features unique to both depression and mania—such as episodes of despair, doubt, anguish, rage or homicidal ideation, suicidal ideat ...

Schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...

, and

Treatment of bipolar disorder The emphasis of the treatment of bipolar disorder is on effective management of the long-term course of the illness, which can involve treatment of emergent symptoms. Treatment methods include pharmacological and psychological techniques. Bipolar D ...

Honors

Tohen has been President of the

International Society for Bipolar Disorders The International Society for Bipolar Disorders (ISBD) is a nonprofit organization based in Pittsburgh, Pennsylvania, where it was founded June 17, 1999. The society focuses on research and education in bipolar disorders. The society has a members ...

(2010–2012) and President of the American Society of Hispanic Psychiatry (2014–2016). In 2016 he was selected by the

National Alliance on Mental Illness The National Alliance on Mental Illness (NAMI) is a United States-based nonprofit organization originally founded as a grassroots group by family members of people diagnosed with mental illness. NAMI identifies its mission as "providing advoca ...

to receive the Exemplary Psychiatrist Award. Also in 2016, the International Society for Bipolar Disorders awarded him the

Mogens Schou Mogens Schou (24 November 1918 – 29 September 2005) was a Denmark, Danish psychiatrist whose research into Lithium pharmacology, lithium led to its utilization as a treatment for bipolar disorder. Early years Schou was born in Copenhagen ...

Award for Education and Teaching. Other honors he has received include a FIRST award from NIMH, the Pope Award from McLean Hospital, a NARSAD Young Investigator Award, and in 2011 the Simon Bolivar Award from the American Psychiatric Association. Tohen was listed by

Thomson Reuters Thomson Reuters Corporation ( ) is a Canadian multinational media conglomerate. The company was founded in Toronto, Ontario, Canada, where it is headquartered at the Bay Adelaide Centre. Thomson Reuters was created by the Thomson Corpora ...

among ''The World's Most Influential Scientific Minds 2014'' in Psychiatry/Psychology, based on citation data of scientists who published work with the highest (top 1%) impact in their fields between 2002 and 2013. His Expertise in Bipolar Disorder is ranked by ''Expertscape'' as Top 0.14% worldwide, based on his articles on the topic published from 2010 through 2020.

Books

Tohen has co-edited four books: *Textbook of Psychiatric Epidemiology (1995 first edition, 2002 second edition & 2011 third edition) *Mood Disorders Across the Life Span (1996) *Bipolar Disorder:The Upswing in Research and Treatment (2005) *Bipolar Psychopharmacotherapy: Caring for the Patient, first edition (2006), second edition (2011) He also edited two books: * Bipolar Disorder: Comorbidity in Affective Disorders (1999) *Clinical Trial Design Challenges in Mood Disorders (2015), first edition

References

{{authority control University of Texas Health Science Center at San Antonio faculty University of New Mexico faculty Harvard Medical School faculty National Autonomous University of Mexico alumni University of Toronto alumni Kelley School of Business alumni Harvard School of Public Health alumni Year of birth missing (living people) Living people