Matthew Dobson (physician)
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Matthew Dobson (1732–1784) was an English physician and experimental
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...
. He is now remembered for his work on
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
.


Life and career

His parents were Joshua Dobson, a nonconformist minister at Lydgate,
West Yorkshire West Yorkshire is a metropolitan and ceremonial county in the Yorkshire and Humber Region of England. It is an inland and upland county having eastward-draining valleys while taking in the moors of the Pennines. West Yorkshire came into exi ...
, and Elizabeth, daughter of Matthew Smith who was minister at Mixenden. He matriculated at
Glasgow University , image = UofG Coat of Arms.png , image_size = 150px , caption = Coat of arms Flag , latin_name = Universitas Glasguensis , motto = la, Via, Veritas, Vita , ...
in 1750, where he graduated MA in 1753. He then moved to
Edinburgh University The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1582 ...
, where he graduated MD in 1756. From the end of the decade he worked as a doctor in
Liverpool Liverpool is a city and metropolitan borough in Merseyside, England. With a population of in 2019, it is the 10th largest English district by population and its metropolitan area is the fifth largest in the United Kingdom, with a popul ...
. Dobson worked with Matthew Turner and others to set up the Liverpool Academy of Art in 1769, a local reply to the
Royal Academy The Royal Academy of Arts (RA) is an art institution based in Burlington House on Piccadilly in London. Founded in 1768, it has a unique position as an independent, privately funded institution led by eminent artists and architects. Its pur ...
's foundation in 1768. After a slow start, a first exhibition was held in 1774. (The 1810 foundation of the
Liverpool Academy of Arts The Liverpool Academy of Arts was founded in Liverpool in April 1810 as a regional equivalent of the Royal Academy, London. It followed the Liverpool Society of Artists, first founded in 1769, which had a fitful existence until 1794. Two local a ...
was in the nature of a fresh beginning.) In 1770 he was appointed physician to Liverpool Infirmary, as successor to John Kennion. He had a house in Harrington Street. When William Enfield wrote his ''History of Leverpool'' (1772), Dobson contributed to it.
James Allanson Picton James Allanson Picton (8 August 1832 – 4 February 1910) was a British independent minister, author, philosopher and Liberal politician. Picton promoted a philosophy known as Christian pantheism. Life Picton was born at Liverpool, the eldest ...
, ''Memorials of Liverpool: historical and topographical, including a history of the Dock Estate'' vol. 2 (1875), pp. 132–133
archive.org.
/ref> About 1776 Dobson gave up his Liverpool practice, which was taken over by Joseph Brandreth. He was elected a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
in 1778, and became head of the Liverpool Medical Library in 1779. In 1780, suffering from poor health, he retired to
Bath, Somerset Bath () is a city in the Bath and North East Somerset unitary area in the county of Somerset, England, known for and named after its Roman-built baths. At the 2021 Census, the population was 101,557. Bath is in the valley of the River Avon, ...
. He joined the
Manchester Literary and Philosophical Society The Manchester Literary and Philosophical Society, popularly known as the Lit. & Phil., is one of the oldest learned societies in the United Kingdom and second oldest provincial learned society (after the Spalding Gentlemen's Society). Promine ...
, established in 1781. Dobson was physician, and eventually confidant to
Hester Thrale Hester Lynch Thrale Piozzi (née Salusbury; later Piozzi; 27 January 1741 or 16 January 1740 – 2 May 1821),Contemporary records, which used the Julian calendar and the Annunciation Style of enumerating years, recorded her birth as 16 January ...
. He played a key role in her second marriage to Gabriel Piozzi, persuading her daughter Queeney to accept Piozzi, whose banishment from the household he said was life-threatening for her mother. Dobson died in Bath on 25 July 1784, incidentally on the day of Hester Thrale's second marriage, and was buried at Walcot. A memorial was put up in Toxteth Park chapel.


Study group

Dobson was part of a medical study group for his local area that met on a quarterly basis.
John Aikin John Aikin (15 January 1747 – 7 December 1822) was an English medical doctor and surgeon. Later in life he devoted himself wholly to biography and writing in periodicals. Life He was born at Kibworth Harcourt, Leicestershire, England, son o ...
of Chester and Warrington took part, with John Bostock,
Thomas Percival Thomas Percival (29 September 1740 – 30 August 1804) was an English physician, health reformer, ethicist and author who wrote an early code of medical ethics. He drew up a pamphlet with the code in 1794 and wrote an expanded version in 18 ...
and
John Haygarth John Haygarth FRS FRSE (1740 – 10 June 1827) was an important 18th-century British physician who discovered new ways to prevent the spread of fever among patients and reduce the mortality rate of smallpox. Life Haygarth was born to William ...
. Dobson provided information on
influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...
in Liverpool for the researches of Haygarth, a classmate from Edinburgh. This group was closely associated with
Joseph Priestley Joseph Priestley (; 24 March 1733 – 6 February 1804) was an English chemist, natural philosopher, separatist theologian, grammarian, multi-subject educator, and liberal political theorist. He published over 150 works, and conducted exp ...
,
Richard Price Richard Price (23 February 1723 – 19 April 1791) was a British moral philosopher, Nonconformist minister and mathematician. He was also a political reformer, pamphleteer, active in radical, republican, and liberal causes such as the French ...
and radical politics. It also cooperated as part of Priestley's attempt to develop "pneumatic therapy": the medical use of newly isolated gases.


Medical work

In his student days, Dobson worked with
William Cullen William Cullen FRS FRSE FRCPE FPSG (; 15 April 17105 February 1790) was a Scottish physician, chemist and agriculturalist, and professor at the Edinburgh Medical School. Cullen was a central figure in the Scottish Enlightenment: He was Dav ...
at
Glasgow University , image = UofG Coat of Arms.png , image_size = 150px , caption = Coat of arms Flag , latin_name = Universitas Glasguensis , motto = la, Via, Veritas, Vita , ...
on
evaporation Evaporation is a type of vaporization that occurs on the surface of a liquid as it changes into the gas phase. High concentration of the evaporating substance in the surrounding gas significantly slows down evaporation, such as when humidi ...
. In 1775 Dobson for the first time identified as a sugar the sweet substance in the
urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cel ...
of patients with
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
. He published his work as ''Experiments and Observations on the Urine in Diabetics'' (1776). It did not have a major clinical impact, the findings being still debated until the work of George Owen Rees in the middle of the 19th century. Dobson observed the sweet taste of the blood of diabetics (caused by
hyperglycemia Hyperglycemia is a condition in which an excessive amount of glucose circulates in the blood plasma. This is generally a blood sugar level higher than 11.1 mmol/L (200  mg/dL), but symptoms may not start to become noticeable until even ...
), and argued that the disease was not located in the
kidneys The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...
, as was believed at the time. Initial use of specialised diets by physicians was not very successful.
John Rollo John Rollo M.D. (d. December 23, 1809) was a Scottish military surgeon, now known for his work on a diabetic diet. Rollo was the first to suggest a low-carbohydrate diet as a treatment for diabetes.Veves, Aristidis; Malik, Rayaz A. (2007). ''Diabe ...
cited Dobson in his research of the late 1790s, and established principles for a
diabetic diet A diabetic diet is a diet that is used by people with diabetes mellitus or high blood sugar to minimize symptoms and dangerous complications of long-term elevations in blood sugar ( i.e.: cardiovascular disease, kidney disease, obesity). Amon ...
. In 1775 Dobson experimented with a heated room as treatment, a line of research already explored by
George Fordyce George Fordyce (18 November 1736 – 25 May 1802) was a distinguished Scotland, Scottish physician, lecturer on medicine, and chemist, who was a Fellow of the Royal Society and a Fellow of the Royal College of Physicians. Early life George Fo ...
and
Charles Blagden Sir Charles Brian Blagden FRS (17 April 1748 – 26 March 1820) was an English physician and chemist. He served as a medical officer in the Army (1776–1780) and later held the position of Secretary of the Royal Society (1784–1797). Blagd ...
. His colleague
Henry Park Henry may refer to: People * Henry (given name) * Henry (surname) * Henry Lau, Canadian singer and musician who performs under the mononym Henry Royalty * Portuguese royalty ** King-Cardinal Henry, King of Portugal ** Henry, Count of Portuga ...
acted as guinea pig. He published the results as a letter to John Fothergill in ''
Philosophical Transactions ''Philosophical Transactions of the Royal Society'' is a scientific journal published by the Royal Society. In its earliest days, it was a private venture of the Royal Society's secretary. It was established in 1665, making it the first journa ...
''. In 1779 Dobson reported success in using "fixed air" (
carbon dioxide Carbon dioxide (chemical formula ) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in the gas state at room temperature. In the air, carbon dioxide is transpar ...
) in the treatment of
scurvy Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, feeling tired and sore arms and legs. Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding ...
. That year he published ''Medical Commentary on Fixed Air''. The 1787 edition had an appendix by William Falconer. The work also advocated fixed air as a treatment for the stone. Dobson was interested in
bladder stone A bladder stone is a stone found in the urinary bladder. Signs and symptoms Bladder stones are small mineral deposits that can form in the bladder. In most cases bladder stones develop when the urine becomes very concentrated or when one is d ...
s from a statistical point of view, too, and gathered data from Norwich Hospital. In fact he made a wider survey of hospitals and their admissions in the 1779 edition, Norwich having the highest proportion of admitted patients for bladder stone. The figures were reprinted by Leonhard Ludwig Finke during the 1790s.A. Batty Shaw, ''The Norwich School of Lithotomy'' (PDF)
at pp. 236–237.


Family

In 1759 Dobson married Susannah Dobson (née Dawson), a translator from French. They had three children, at least two of whom were baptised at the
Octagon Chapel, Liverpool The Octagon Chapel, Liverpool, was a nonconformist church in Liverpool, England, opened in 1763. It was founded by local congregations, those of Benn's Garden and Kaye Street chapels. The aim was to use a non-sectarian liturgy; Thomas Bentle ...
. Dobson was an associate of
Thomas Bentley Thomas Bentley (23 February 1884 – 23 December 1966) was a British film director. He directed 68 films between 1912 and 1941. He directed three films in the early DeForest Phonofilm sound-on-film process, ''The Man in the Street'' (1926), '' ...
in the construction of the chapel; and Nicholas Clayton, a classmate from Glasgow, was the first minister.


Notes

{{DEFAULTSORT:Dobson, Matthew 1732 births 1784 deaths 18th-century English medical doctors English physiologists Fellows of the Royal Society