The mammalian CPEB3 ribozyme is a self cleaving
non-coding RNA
A non-coding RNA (ncRNA) is a functional RNA molecule that is not Translation (genetics), translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally im ...
located in the second
intron of the
CPEB3 gene which belongs to a family of genes regulating messenger RNA
polyadenylation.
This ribozyme is highly conserved and
found only in mammals.
The CPEB3 ribozyme is structurally and biochemically related to the human
hepatitis delta virus ribozyme
The hepatitis delta virus (HDV) ribozyme is a non-coding RNA found in the hepatitis delta virus that is necessary for viral replication and is the only known human virus that utilizes ribozyme activity to infect its host. The ribozyme acts to pr ...
.
Other HDV-like ribozymes have been identified and confirmed to be active ''in vitro'' in a number of eukaryotes.
References
External links
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Non-coding RNA
Ribozymes
RNA splicing
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