Mallotophenone is a dimeric phloroglucinol found in ''

Mallotus oppositifolius ''Mallotus oppositifolius'' is a plant species in the genus ''Mallotus'' found in Africa and Madagascar. The variety ''Mallotus oppositifolius'' var. ''lindicus'' is classified in the IUCN red list of vulnerable species of plants. The aqueous ...

'' or in ''

Mallotus japonicus ''Mallotus japonicus'' (), also known as East Asian mallotus, the food wrapper plant or "Akamegashiwa" in Japanese, is a plant species in the genus ''Mallotus'' native to China. It is also found in Japan and Korea. This species was first describe ...

''. The

bioassay-guided fractionation Fractionation is a separation process in which a certain quantity of a mixture (of gases, solids, liquids, enzymes, or isotopes, or a suspension) is divided during a phase transition, into a number of smaller quantities (fractions) in which t ...

of an ethanol extract of the leaves and inflorescence of ''M. oppositifolius'' collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotophenone, together with mallotojaponins B and C. These compounds show

antiproliferative Cytostasis (cyto – cell; stasis – stoppage) is the inhibition of cell growth and multiplication. Cytostatic refers to a cellular component or medicine that inhibits cell division. Cytostasis is an important prerequisite for structured multic ...

and

antiplasmodial ''Plasmodium'' is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of ''Plasmodium'' species involve development in a blood-feeding insect host which then injects parasites into a verteb ...

activities.

References

Phloroglucinols Natural phenol dimers {{aromatic-stub