Myosin-Vb,
a myosin V type protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
, is encoded by the ''MYO5B''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
in humans.
Recent evidence suggests that Myosin-Vb is related to the creation of memories
by
actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ov ...
-dependent trafficking of
AMPA receptor containing recycling endosomes in
dendritic spines
A dendritic spine (or spine) is a small membranous protrusion from a neuron's dendrite that typically receives input from a single axon at the synapse. Dendritic spines serve as a storage site for synaptic strength and help transmit electrical si ...
.
Mutations of MYO5B cause
microvillus inclusion disease due to defective trafficking of
apical and basolateral proteins.
MYO5B has also been associated with bipolar disorder.
Interactions
MYO5B has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
RAB11FIP2.
References
Further reading
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External links
GeneTests/NIH/NCBI/UW information Diarrhea with Microvillus Atrophy 2 DIAR2 Microvillus Inclusion Disease MVID gene testing
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