ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a
protein that in humans is encoded by the ''ABCC4''
gene.
ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cyclic adenosine monophosphate, cAMP-dependent signal transduction to the nucleus.
MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.
MRP4/ABCC4 expression is dysregulated in several cancers and is also upregulated in peritoneal endometriosis.
Interactive pathway map
See also
* ATP-binding cassette transporter
References
Further reading
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External links
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{{DEFAULTSORT:Abcc4
ATP-binding cassette transporters