mRNA-5671 also known as V941 is a

cancer vaccine A cancer vaccine is a vaccine that either treats existing cancer or prevents development of cancer. Vaccines that treat existing cancer are known as ''therapeutic'' cancer vaccines or tumor antigen vaccines. Some of the vaccines are "autologous", ...

candidate developed by Moderna. It is a tetravalent vaccine that targets G12D, G12V, G13D or G12C driver mutations in the KRAS gene. It is currently being evaluated for the treatment of either non-small cell lung cancer,

colorectal cancer Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel m ...

s with

microsatellite instability Microsatellite instability (MSI) is the condition of genetic hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair (MMR). The presence of MSI represents phenotypic evidence that MMR is not functioning normal ...

, or

pancreatic adenocarcinoma Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancerous cells have the ability to invade other parts of the body. A number of types of pancre ...

, all with confirmed KRAS driver mutations.

References

Cancer vaccines RNA vaccines {{vaccine-stub