Microsomal prostaglandin E synthase-1 (mPGES-1)
or Prostaglandin E synthase is an
enzyme that in humans is encoded by the ''PTGES''
gene.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by
proinflammatory cytokine An inflammatory cytokine or proinflammatory cytokine is a type of signaling molecule (a cytokine) that is secreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation. They include inte ...
interleukin 1 beta
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the ''IL1B'' gene."Catabolin" ...
(IL1B). Its expression can also be induced by
tumor suppressor protein
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or red ...
TP53, and may be involved in TP53-induced
apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...
.
Knockout studies in mice suggest that this gene may contribute to the pathogenesis of
collagen-induced arthritis
Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.
CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen
Type II collagen is the basis ...
and mediate acute pain during inflammatory responses.
See also
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Prostaglandin E synthase
Prostaglandin E synthase (, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.
The synthase generating PGE2 is a membrane-associated ...
References
Further reading
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