The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of
pathogen related products. It has an immunoglobulin-like
beta-sandwich
Beta-sandwich, β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins. They are characterized by two opposing antiparallel beta sheets (β-sheets). The number of strands found in such domains may differ from one protein ...
fold similar to that of
immunoglobulin
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
E-set domains. This domain is present in the following proteins:
*
Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind
cholesterol.
Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of
low-density lipoprotein-derived
cholesterol in
lysosomes.
*
House dust mite allergen proteins such as
Der f 2
Der or DER may refer to:
Places
* Darkənd, Azerbaijan
* Dearborn (Amtrak station) (station code), in Michigan, US
* Der (Sumer), an ancient city located in modern-day Iraq
* d'Entrecasteaux Ridge, an oceanic ridge in the south-west Pacific Ocean ...
from ''
Dermatophagoides farinae
House dust mites (HDM, or simply dust mites) are various species of Acariformes, acariform mites belonging to the family Pyroglyphidae that are found in association with dust in dwellings. They are known for causing dust mite allergy, allergies. ...
'' and
Der p 2
Der or DER may refer to:
Places
* Darkənd, Azerbaijan
* Dearborn (Amtrak station) (station code), in Michigan, US
* Der (Sumer), an ancient city located in modern-day Iraq
* d'Entrecasteaux Ridge, an oceanic ridge in the south-west Pacific Ocean ...
from ''
Dermatophagoides pteronyssinus''.
Human proteins containing this domain
LY86;
LY96;
MMD-1;
References
{{InterPro content, IPR003172
Protein domains
Protein families