Muscular LMNA interacting protein (MLIP) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''MLIP''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
The function of MLIP is not known but it has been suggested that it may have a role in the growth of the heart and heart disease. There is some evidence that MLIP may be involved in maintaining cardiac homeostasis and in the initial reaction to changes in workload. However, a
knockout mouse
A knockout mouse, or knock-out mouse, is a genetically modified mouse (''Mus musculus'') in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are importan ...
model had normal cardiac function and no structural abnormalities, showing that MLIP is not vital to these processes.
Gene
Aliases
Muscular LMNA interacting protein has a number of aliases including MLIP, C6orf142, CIP and Muscle-enriched A-type Lamin-interacting Protein.
Locus and size
''MLIP'' is located on the short arm of chromosome 6 in humans with the exact locus of 6p12.1. The gene spans 53929982 to 54266280 on the + strand of chromosome 6.
It has 19
exon
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term ''exon'' refers to both the DNA sequence within a gene and to the corresponding sequen ...
s and 13
splice variants ranging in size from 23 to 57
kDa.
[
]
Orthologs and homologs
MLIP is found only in
amniote
Amniotes are a clade of tetrapod vertebrates that comprises sauropsids (including all reptiles and birds, and extinct parareptiles and non-avian dinosaurs) and synapsids (including pelycosaurs and therapsids such as mammals). They are disti ...
s (reptiles, birds and mammals), where it is highly
conserved. The mouse homologue is 2310046A06rik.
Expression and interactions
''MLIP'' is
expressed throughout the body with higher levels found in the heart and muscle cells. It interacts with the
nuclear envelope
The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material.
The nuclear envelope consists of two lipid bilayer membrane ...
proteins
lamin A/C, which is what led to its discovery. It also interacts with Islet1 transcription factor.
References
External links
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Further reading
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