MK-212 (CPP or 6-chloro-2-(1-piperazinyl)pyrazine) is a
serotonin agonist
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the ...
. It promotes the secretion of serum
prolactin
Prolactin (PRL), also known as lactotropin, is a protein best known for its role in enabling mammals to produce milk. It is influential in over 300 separate processes in various vertebrates, including humans. Prolactin is secreted from the pit ...
and
cortisol in humans.
Pharmacology
In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects.
The result correlated very well to binding of indolealkylamine receptors, such as the
serotonin and
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...
receptors, which shows four characteristics. Namely, increased frequency of muscle twitching,
increased twitching of the head,
"an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.
See also
*
2C-B-PP
2,5-dimethoxy-4-bromophenylpiperazine (2C-B-PP) is a drug of the phenylpiperazine class. It acts as an agonist at serotonin receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled rece ...
*
mCPP
*
ORG-12962
ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-a ...
*
Quipazine
Quipazine is a serotonergic drug of the piperazine group which is used in scientific research. It was originally intended as an antidepressant but never developed for medical use.
Pharmacology
Pharmacodynamics
Quipazine is a serotonin reuptake ...
References
{{piperazines
Chloroarenes
Piperazines
Pyrazines
Serotonin receptor agonists