In molecular biology, Maternally expressed 8 (non-protein coding), also known as MEG8 or Rian (RNA Imprinted and Accumulated in Nucleus), is a
long non-coding RNA
Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as mic ...
. It is an
imprinted gene, which is
maternal
]
A mother is the female parent of a child. A woman may be considered a mother by virtue of having given birth, by raising a child who may or may not be her biological offspring, or by supplying her ovum for fertilisation in the case of gestat ...
ly expressed. It is expressed in the
Cell nucleus, nucleus and (in an eight-week-old sheep) is preferentially expressed in
skeletal muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscl ...
.
See also
*
Long noncoding RNA
Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as mic ...
References
Further reading
* {{cite journal , vauthors = Cavaillé J, Seitz H, Paulsen M, Ferguson-Smith AC, Bachellerie JP , title = Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region , journal = Human Molecular Genetics , volume = 11 , issue = 13 , pages = 1527–38 , date = June 2002 , pmid = 12045206 , doi = 10.1093/hmg/11.13.1527 , doi-access = free
Non-coding RNA