Melanin-concentrating hormone receptor 2 (MCH₂) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the ''MCHR2'' gene. MCH₂ is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of

IDH3A Isocitrate dehydrogenase ADsubunit alpha, mitochondrial (IDH3α) is an enzyme that in humans is encoded by the ''IDH3A'' gene. Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes ...

PCK1 Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the ''PCK1'' gene. Function This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by ...

and

PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 also known as PFKFB4 is an enzyme which in humans is encoded by the ''PFKFB4'' gene. Function The bifunctional 6-phosphofructo-2-kinase ()/fructose-2,6-bisphosphatase () (PFKFB) regulates t ...

and the downregulation of INSIG2 and

ACOT8 Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ''ACOT8'' gene. The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their form ...

Clinical significance

See also

References

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Further reading